Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton - Sorbonne Université Access content directly
Journal Articles Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-...] Year : 2023

Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton

Abstract

Hydrogen polysulfide (H 2 S n , n>1) has a valuable function in various aspects of biological regulation. Therefore, it is of great significance to realize the visual monitoring of H 2 S n levels in vivo. Herein, a series of fluorescent probes NR-BS were constructed by changing types and positions of substituents on the benzene ring of benzenesulfonyl. Among them, probe NR-BS4 was optimized due to its wide linear range (0~350 μM) and little interference from biothiols. In addition, NR-BS4 has a broad pH tolerance range (pH = 4~10) and high sensitivity (0.140 μM). In addition, the PET mechanism of probe NR-BS4 and H 2 S n was demonstrated by DFT calculations and LC-MS. The intracellular imaging studies indicate that NR-BS4 can be successfully devoted to monitor the levels of exogenous and endogenous H 2 S n in vivo.
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Dates and versions

hal-04050695 , version 1 (29-03-2023)

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Qian Feng, Yiming Song, Yixuan Ma, Yan Deng, Pengyue Xu, et al.. Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2023, 296, pp.122658. ⟨10.1016/j.saa.2023.122658⟩. ⟨hal-04050695⟩
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