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Journal Articles The Journal of Allergy and Clinical Immunology: In Practice Year : 2023

Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory Conditions

Abstract

Intravenous immunoglobulin (IVIG) is the mainstay of therapy for humoral immune deficiencies and numerous inflammatory disorders. Although the use of IVIG may be supplanted by several targeted therapies to cytokines, the ability of polyclonal normal IgG to act as an effector molecule as well as a regulatory molecule is a clear example of the polyfunctionality of IVIG. This article will address the mechanism of action of IVIG in a number of important conditions that are otherwise resistant to treatment. In this commentary, we will highlight mechanistic studies that shed light on the action of IVIG. This will be approached by identifying effects that are both common and disease-specific, targeting actions that have been demonstrated on cells and processes that represent both innate and adaptive immune responses
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Dates and versions

hal-04088150 , version 1 (03-05-2023)

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Jagadeesh Bayry, Eisha Ahmed, Diana Toscano-Rivero, Nicholas Vonniessen, Genevieve Genest, et al.. Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory Conditions. The Journal of Allergy and Clinical Immunology: In Practice, 2023, ⟨10.1016/j.jaip.2023.04.002⟩. ⟨hal-04088150⟩
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