In solution, hypochlorous acid (HOCl) reacts with organic matter and notably with protein side-chains. In this study, HOCl was produced by an electrochemical way, by oxidation of chloride ions at a transparent tin dioxide electrode in the presence of a protein, the bovine serum albumin (BSA). A thick irregular layer is formed at the electrode when HOCl is produced at the SnO2 surface. Indeed, SEM analyses show that an important deposit is formed during the anodic polarization of SnO2 in the presence of chloride ions and proteins. Actually, two phenomena take place on the one hand the chlorination of the proteins due to the reaction of HOCl with some protein side-chains and on the other hand the aggregation of proteins onto the SnO2 surface. The present X-ray photoelectron spectroscopy study points out the cross-linking of BSA molecules via formation of inter molecular sulfonamide groups. It also shows that the BSA chlorination is due on the one hand to the formation of sulfonyl chloride groups (–SO2Cl) and on the other hand to formation of chloramine groups (2 bonds on the lefthand sideN–Cl). The Cl2p and S2p photo-peak intensities allowed us to quantify the chloramines. It is found that, one BSA entity immobilized onto the SnO2 surface contains about 50 chloramine groups.