C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis - Sorbonne Université Access content directly
Journal Articles Beilstein Journal of Organic Chemistry Year : 2023

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

Grédy Kiala Kinkutu
  • Function : Author
Catherine Louis
  • Function : Author
Myriam Roy

Abstract

The C3-functionalization of furfural using homogeneous ruthenium catalysts requires the preinstallation of an ortho -directing imine group, as well as high temperatures, which did not allow scaling up, at least under batch conditions. In order to design a safer process, we set out to develop a continuous flow process specifically for the C3-alkylation of furfural (Murai reaction). The transposition of a batch process to a continuous flow process is often costly in terms of time and reagents. Therefore, we chose to proceed in two steps: the reaction conditions were first optimized using a laboratory-built pulsed-flow system to save reagents. The optimized conditions in this pulsed-flow mode were then successfully transferred to a continuous flow reactor. In addition, the versatility of this continuous flow device allowed both steps of the reaction to be carried out, namely the formation of the imine directing group and the C3-functionalization with some vinylsilanes and norbonene.
Fichier principal
Vignette du fichier
1860-5397-19-43.pdf (3.37 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-04217003 , version 1 (25-09-2023)

Identifiers

Cite

Grédy Kiala Kinkutu, Catherine Louis, Myriam Roy, Juliette Blanchard, Julie Oble. C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis. Beilstein Journal of Organic Chemistry, 2023, 19, pp.582-592. ⟨10.3762/bjoc.19.43⟩. ⟨hal-04217003⟩
34 View
13 Download

Altmetric

Share

Gmail Facebook X LinkedIn More