Faecal microbiota transplantation to prevent complications after allogeneic stem cell transplantation for haematological malignancies: a study protocol for a randomised controlled phase-II trial (the FMT-allo study) - Sorbonne Université Access content directly
Journal Articles BMJ Open Year : 2023

Faecal microbiota transplantation to prevent complications after allogeneic stem cell transplantation for haematological malignancies: a study protocol for a randomised controlled phase-II trial (the FMT-allo study)

Aurore Dougé
  • Function : Author
Aurélie Ravinet
  • Function : Author
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Alexandrine Corriger
Aurélie Cabrespine
  • Function : Author
Mathieu Wasiak
  • Function : Author
Bruno Pereira
  • Function : Author
Harry Sokol
  • Function : Author

Abstract

Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) is a major treatment for many haematological malignancies. The procedure has a good success rate but high transplant-related toxicity (TRM). TRM is mostly related to graft-versus- host disease (GvHD) and infectious complications. Alterations of the intestinal microbiota plays a major role in the development of allo- HSCT complications. The gut microbiota could be restored by faecal microbiota transplantation (FMT). However, there are no published randomised studies assessing the efficacy of FMT for GvHD prophylaxis.
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Dates and versions

hal-04251279 , version 1 (20-10-2023)

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Aurore Dougé, Aurélie Ravinet, Alexandrine Corriger, Aurélie Cabrespine, Mathieu Wasiak, et al.. Faecal microbiota transplantation to prevent complications after allogeneic stem cell transplantation for haematological malignancies: a study protocol for a randomised controlled phase-II trial (the FMT-allo study). BMJ Open, 2023, 13 (5), pp.1-10. ⟨10.1136/bmjopen-2022-068480⟩. ⟨hal-04251279⟩
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