Faecal microbiota transplantation to prevent complications after allogeneic stem cell transplantation for haematological malignancies: a study protocol for a randomised controlled phase-II trial (the FMT-allo study)
Résumé
Allogeneic haematopoietic stem-cell
transplantation (allo-HSCT) is a major treatment for many
haematological malignancies. The procedure has a good
success rate but high transplant-related toxicity (TRM).
TRM is mostly related to graft-versus- host disease (GvHD)
and infectious complications. Alterations of the intestinal
microbiota plays a major role in the development of allo-
HSCT complications. The gut microbiota could be restored
by faecal microbiota transplantation (FMT). However,
there are no published randomised studies assessing the
efficacy of FMT for GvHD prophylaxis.
| Origine | Publication financée par une institution |
|---|