How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients - Sorbonne Université Access content directly
Journal Articles Rheumatology Year : 2024

How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients

Conor Coyle
  • Function : Author
Lily Watson
  • Function : Author
Caroline Whately-Smith
  • Function : Author
Mel Brooke
  • Function : Author
Uta Kiltz
  • Function : Author
Ennio Lubrano
  • Function : Author
Ruben Queiro
  • Function : Author
David Trigos
  • Function : Author
Jan Brandt-Juergens
  • Function : Author
Ernest Choy
  • Function : Author
Salvatore D Angelo
  • Function : Author
Andrea Delle Sedie
  • Function : Author
Emmanuelle Dernis
  • Function : Author
Théo Wirth
  • Function : Author
Sandrine Guis
  • Function : Author
Philip Helliwell
  • Function : Author
Pauline Ho
  • Function : Author
Axel Hueber
  • Function : Author
Beatriz Joven
  • Function : Author
Michaela Koehm
  • Function : Author
Carlos Montilla Morales
  • Function : Author
Jon Packham
  • Function : Author
Jose Antonio
  • Function : Author
Pinto Tasende
  • Function : Author
Felipe Julio Ramirez
  • Function : Author
Adeline Ruyssen-Witrand
  • Function : Author
Rossana Scrivo
  • Function : Author
Sarah Twigg
  • Function : Author
Martin Welcker
  • Function : Author
Martin Soubrier
Laura C Coates
  • Function : Author

Abstract

Abstract Objectives The ASSIST study investigated prescribing in routine psoriatic arthritis (PsA) care and whether the patient reported outcome: PsA Impact of Disease questionnaire (PsAID-12), impacted treatment. This study also assessed a range of patient and clinician factors and their relationship to PsAID-12 scoring and treatment modification. Methods Patients with PsA were selected across the UK and Europe between July 2021-March 2022. Patients completed the PsAID questionnaire, with the results shared with their physician. Patient characteristics, disease activity, current treatment methods, treatment strategies, medication changes and patient satisfaction scores were recorded. Results 503 patients recruited. 36.2% had changes made to treatment, 88.8% of this had treatment escalation. Overall, the mean PsAID-12 score was higher for patients with treatment escalation; the PsAID-12 score was associated with odds of treatment escalation (OR: 1.58; p< 0.0001). However, most clinicians reported PsAID-12 did not impact their decision to escalate treatment, instead supporting treatment reduction decisions. Physician’s assessment of disease activity had the most statistically significant effect on likelihood of treatment escalation, (OR = 2.68, per 1-point score increase). Escalation was more likely in patients not treated with biologic therapies. Additional factors associated with treatment escalation included: patient characteristics, physician characteristics, disease activity and disease impact. Conclusion This study highlights multiple factors impacting treatment decision making for individuals with PsA. PsAID-12 scoring correlates with multiple measures of disease severity and odds of treatment escalation. However, most clinicians reported the PsAID-12 did not influence treatment escalation decisions. PsAID scoring could be used to increase confidence in treatment de-escalation.
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Dates and versions

hal-04404884 , version 1 (19-01-2024)

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Conor Coyle, Lily Watson, Caroline Whately-Smith, Mel Brooke, Uta Kiltz, et al.. How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients. Rheumatology, In press, ⟨10.1093/rheumatology/kead679/7513167⟩. ⟨hal-04404884⟩
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