Pain-phenotyping in osteoarthritis: Current concepts, evidence, and considerations towards a comprehensive framework for assessment and treatment - Sorbonne Université
Journal Articles Osteoarthritis and Cartilage Open Year : 2024

Pain-phenotyping in osteoarthritis: Current concepts, evidence, and considerations towards a comprehensive framework for assessment and treatment

F. Saxer
A. Hollinger
M.F. Bjurström
P.G. Conaghan
T. Neogi
M. Schieker

Abstract

Objectives: Pain as central symptom of osteoarthritis (OA) needs to be addressed as part of successful treatment. The assessment of pain as feature of disease or outcome in clinical practice and drug development remains a challenge due to its multidimensionality and the plethora of confounders. This article aims at providing insights into our understanding of OA pain-phenotypes and suggests a framework for systematic and comprehensive assessments. Methods: This narrative review is based on a search of current literature for various combinations of the search terms "pain-phenotype" and "knee OA" and summarizes current knowledge on OA pain-phenotypes, putting OA pain and its assessment into perspective of current research efforts. Results: Pain is a complex phenomenon, not necessarily associated with tissue damage. Various pain-phenotypes have been described in knee OA. Among those, a phenotype with high pain levels not necessarily matching structural changes and a phenotype with low pain levels and impact are relatively consistent. Further subgroups can be differentiated based on patient reported outcome measures, assessments of comorbidities, anxiety and depression, sleep, activity and objective measures such as quantitative sensory testing. Conclusions: The complexity of both OA as disease and pain in OA prompt the definition of a set of variables that facilitate assessments comparable across studies to maximize our understanding of pain, as central concern for the patient.
Fichier principal
Vignette du fichier
OCARTO-D-23-00084_R1 Manuscript.pdf (1.28 Mo) Télécharger le fichier
OCARTO-D-23-00084_R1 Supplement 1.pdf (398.52 Ko) Télécharger le fichier
OCARTO-D-23-00084_R1 Supplement 2.pdf (600.29 Ko) Télécharger le fichier
OCARTO-D-23-00084_R1 Supplement 3.pdf (430.11 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Origin Files produced by the author(s)

Dates and versions

hal-04405762 , version 1 (19-01-2024)

Identifiers

Cite

F. Saxer, A. Hollinger, M.F. Bjurström, P.G. Conaghan, T. Neogi, et al.. Pain-phenotyping in osteoarthritis: Current concepts, evidence, and considerations towards a comprehensive framework for assessment and treatment. Osteoarthritis and Cartilage Open, 2024, 6 (1), pp.100433. ⟨10.1016/j.ocarto.2023.100433⟩. ⟨hal-04405762⟩
19 View
161 Download

Altmetric

Share

More