Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Neha Prakash; Chelsea Caspell-Garcia; Christopher Coffey; Andrew Siderowf; Caroline M Tanner; Karl Kieburtz; Brit Mollenhauer; Douglas Galasko; Kalpana Merchant; Tatiana Foroud; Lana M Chahine; Daniel Weintraub; Cindy Casaceli; Ray Dorsey; Renee Wilson; Margaret Herzog; Nichole Daegele; Vanessa Arnedo; Mark Frasier; Todd Sherer; Ken Marek; Samuel Frank; Danna Jennings; Tanya Simuni; John Seibyl; Duygu Tosun-Turgut; Leslie Shaw; John Trojanowski; Andrew Singleton; Arthur Toga; Werner Poewe; Kathleen Poston; Sohini Chowdhury; Catherine Kopil; Kenneth Marek; Cynthia Casaceli; Sugi Mahes; John Seibyl; Christina Salerno; Arthur Toga; Karen Crawford; Paola Casalin; Giulia Malferrari; Mali Gani Weisz; Avi Orr-Urtreger; John Trojanowski; Leslie Shaw; Andrew Singleton; Thomas Montine; David Russell; Nabila Dahodwala; Werner Poewe; Nir Giladi; Stewart Factor; Penelope Hogarth; David Standaert; Robert Hauser; Joseph Jankovic; Marie Saint-Hilaire; Irene Richard; David Shprecher; Hubert Fernandez; Katrina Brockmann; Liana Rosenthal; Paolo Barone; Alberto Espay; Dominic Rowe; Karen Marder; Anthony Santiago; Susan Bressman; Shu-Ching Hu; Stuart Isaacson; Jean-Christophe Corvol; Javiar Ruiz Martinez; Eduardo Tolosa; Yen Tai; Marios Politis; Debra Smejdir; Linda Rees; Karen Williams; Farah Kausar; Karen Williams; Whitney Richardson; Diana Willeke; Shawnees Peacock; Beatrice Heim; Anat Mirelman; Barbara Sommerfeld; Alison Freed; Katrina Wakeman; Courtney Blair; Stephanie Guthrie; Leigh Harrell; Christine Hunter; Cathi-Ann Thomas; Raymond James; Grace Zimmerman; Victoria Brown; Jennifer Mule; Ella Hilt; Kori Ribb; Susan Ainscough; Misty Wethington; Madelaine Ranola; Helen Mejia Santana; Juliana Moreno; Deborah Raymond; Krista Speketer; Lisbeth Carvajal; Stephanie Carvalho; Ioana Croitoru; Alicia Garrido; Laura Marie Payne; Veena Viswanth; Lawrence Severt; Maurizio Facheris; Holly Soares; Mark A Mintun; Jesse Cedarbaum; Peggy Taylor; Kevin Biglan; Emily Vandenbroucke; Zulfiqar Haider Sheikh; Baris Bingol; Tanya Fischer; Pablo Sardi; Remi Forrat; Alastair Reith; Jan Egebjerg; Gabrielle Ahlberg Hillert; Barbara Saba; Chris Min; Robert Umek; Joe Mather; Susan de Santi; Anke Post; Frank Boess; Kirsten Taylor; Igor Grachev; Andreja Avbersek; Pierandrea Muglia; Kaplana Merchant; Johannes Tauscher

doi:10.1016/j.parkreldis.2018.12.025

Journal Articles Parkinsonism & Related Disorders Year : 2019

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

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Neha Prakash

Function : Author
PersonId : 1343380

Feinberg School of Medicine [Northwestern University, Evanston]

Chelsea Caspell-Garcia

Function : Author

University of Iowa [Iowa City]

Christopher Coffey

Function : Author
PersonId : 1343381

University of Iowa [Iowa City]

Andrew Siderowf

Function : Author
PersonId : 1343382

University of Pennsylvania

Caroline M Tanner

Function : Author

University of California

Karl Kieburtz

Function : Author

University of Rochester Medical Center

Brit Mollenhauer

Function : Author
PersonId : 1343383

University Medical Center Göttingen

Douglas Galasko

Function : Author

University of California [San Diego]

Kalpana Merchant

Function : Author

TransThera Consulting Co

Tatiana Foroud

Function : Author
PersonId : 1343384

Lana M Chahine

Function : Author
PersonId : 1343385

University of Pittsburgh

Daniel Weintraub

Function : Author
PersonId : 1343386

University of Pennsylvania

Cindy Casaceli

Function : Author
PersonId : 1343387

University of Rochester Medical Center

Ray Dorsey

Function : Author
PersonId : 1343388

University of Rochester Medical Center

Renee Wilson

Function : Author
PersonId : 1343389

University of Rochester Medical Center

Margaret Herzog

Function : Author

The Michael J Fox Foundation for Parkinson's Research

Nichole Daegele

Function : Author
PersonId : 1343390

Vanessa Arnedo

Function : Author

The Michael J Fox Foundation for Parkinson's Research

Mark Frasier

Function : Author

The Michael J Fox Foundation for Parkinson's Research

Todd Sherer

Function : Author
PersonId : 1343391

The Michael J Fox Foundation for Parkinson's Research

Ken Marek

Function : Author

Samuel Frank

Function : Author
PersonId : 1343392

Beth Israel Deaconess Medical Center [Boston]

Danna Jennings

Function : Author

Denali Therapeutics [San Francisco, CA, USA].

Tanya Simuni

Function : Author
PersonId : 1343393
ORCID : 0000-0002-2347-1644

Feinberg School of Medicine [Northwestern University, Evanston]

John Seibyl

Function : Author

Duygu Tosun-Turgut

Function : Author

Leslie Shaw

Function : Author

John Trojanowski

Function : Author

Andrew Singleton

Function : Author

Arthur Toga

Function : Author

Werner Poewe

Function : Author

Kathleen Poston

Function : Author

Sohini Chowdhury

Function : Author

Catherine Kopil

Function : Author

Kenneth Marek

Function : Author

Cynthia Casaceli

Function : Author

Sugi Mahes

Function : Author

John Seibyl

Function : Author

Christina Salerno

Function : Author

Arthur Toga

Function : Author

Karen Crawford

Function : Author

Paola Casalin

Function : Author

Giulia Malferrari

Function : Author

Mali Gani Weisz

Function : Author

Avi Orr-Urtreger

Function : Author

John Trojanowski

Function : Author

Leslie Shaw

Function : Author

Andrew Singleton

Function : Author

Thomas Montine

Function : Author

David Russell

Function : Author

Nabila Dahodwala

Function : Author

Werner Poewe

Function : Author

Nir Giladi

Function : Author

Stewart Factor

Function : Author

Penelope Hogarth

Function : Author

David Standaert

Function : Author

Robert Hauser

Function : Author

Joseph Jankovic

Function : Author

Marie Saint-Hilaire

Function : Author

Irene Richard

Function : Author

David Shprecher

Function : Author

Hubert Fernandez

Function : Author

Katrina Brockmann

Function : Author

Liana Rosenthal

Function : Author

Paolo Barone

Function : Author

Alberto Espay

Function : Author

Dominic Rowe

Function : Author

Karen Marder

Function : Author

Anthony Santiago

Function : Author

Susan Bressman

Function : Author

Shu-Ching Hu

Function : Author

Stuart Isaacson

Function : Author

Jean-Christophe Corvol

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Institut du Cerveau = Paris Brain Institute

Javiar Ruiz Martinez

Function : Author

Eduardo Tolosa

Function : Author

Yen Tai

Function : Author

Marios Politis

Function : Author

Debra Smejdir

Function : Author

Linda Rees

Function : Author

Karen Williams

Function : Author

Farah Kausar

Function : Author

Karen Williams

Function : Author

Whitney Richardson

Function : Author

Diana Willeke

Function : Author

Shawnees Peacock

Function : Author

Beatrice Heim

Function : Author

Anat Mirelman

Function : Author

Barbara Sommerfeld

Function : Author

Alison Freed

Function : Author

Katrina Wakeman

Function : Author

Courtney Blair

Function : Author

Stephanie Guthrie

Function : Author

Leigh Harrell

Function : Author

Christine Hunter

Function : Author

Cathi-Ann Thomas

Function : Author

Raymond James

Function : Author

Grace Zimmerman

Function : Author

Victoria Brown

Function : Author

Jennifer Mule

Function : Author

Ella Hilt

Function : Author

Kori Ribb

Function : Author

Susan Ainscough

Function : Author

Misty Wethington

Function : Author

Madelaine Ranola

Function : Author

Helen Mejia Santana

Function : Author

Juliana Moreno

Function : Author

Deborah Raymond

Function : Author

Krista Speketer

Function : Author

Lisbeth Carvajal

Function : Author

Stephanie Carvalho

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Ioana Croitoru

Function : Author

Alicia Garrido

Function : Author

Laura Marie Payne

Function : Author

Veena Viswanth

Function : Author

Lawrence Severt

Function : Author

Maurizio Facheris

Function : Author

Holly Soares

Function : Author

Mark A Mintun

Function : Author

Jesse Cedarbaum

Function : Author

Peggy Taylor

Function : Author

Kevin Biglan

Function : Author

Emily Vandenbroucke

Function : Author

Zulfiqar Haider Sheikh

Function : Author

Baris Bingol

Function : Author

Tanya Fischer

Function : Author

Pablo Sardi

Function : Author

Remi Forrat

Function : Author

Alastair Reith

Function : Author

Jan Egebjerg

Function : Author

Gabrielle Ahlberg Hillert

Function : Author

Barbara Saba

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Chris Min

Function : Author

Robert Umek

Function : Author

Joe Mather

Function : Author

Susan de Santi

Function : Author

Anke Post

Function : Author

Frank Boess

Function : Author

Kirsten Taylor

Function : Author

Igor Grachev

Function : Author

Andreja Avbersek

Function : Author

Pierandrea Muglia

Function : Author

Kaplana Merchant

Function : Author

Johannes Tauscher

Function : Author

Abstract

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC). Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants. Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. All PPMI participants undergo LP at baseline, 6, 12 months and yearly thereafter. CSF collection is performed by a trained investigator using predominantly atraumatic needles. Adverse events (AEs) are monitored by phone one week after LP completion. We analyzed safety data from baseline LPs. Results: PPMI enrolled 683 participants (423 PD/196 HC/64 SWEDDs) from 23 study sites. CSF was collected at baseline in 97.5% of participants, of whom 5.4% underwent collection under fluoroscopy. 23% participants reported any related AEs, 68% of all AE were mild while 5.6% were severe. The most common AEs were headaches (13%) and low back pain (6.5%) and both occurred more commonly in HC and SWEDDs compared to PD participants. Factors associated with higher incidence of AEs across the cohorts included female gender, younger age and use of traumatic needles with larger diameter. AEs largely did not impact compliance with the future LPs. Conclusions: LPs are safe and feasible in PD research participants. Specific LP techniques (needle type and gauge) may reduce the overall incidence of AEs.

Keywords

Adverse events Lumbar puncture Parkinson's disease Safety

Domains

Life Sciences [q-bio]

Gestionnaire HAL 4 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-04423774

Submitted on : Monday, January 29, 2024-12:08:26 PM

Last modification on : Tuesday, November 19, 2024-2:04:09 PM

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hal-04423774 , version 1 (29-01-2024)

Identifiers

HAL Id : hal-04423774 , version 1
DOI : 10.1016/j.parkreldis.2018.12.025
PUBMED : 30738748
PUBMEDCENTRAL : PMC8978879

Cite

Neha Prakash, Chelsea Caspell-Garcia, Christopher Coffey, Andrew Siderowf, Caroline M Tanner, et al.. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI). Parkinsonism & Related Disorders, 2019, 62, pp.201-209. ⟨10.1016/j.parkreldis.2018.12.025⟩. ⟨hal-04423774⟩

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Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

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