Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI) - Sorbonne Université
Journal Articles Parkinsonism & Related Disorders Year : 2019

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Neha Prakash (1) , Chelsea Caspell-Garcia (2) , Christopher Coffey (2) , Andrew Siderowf (3) , Caroline M Tanner (4) , Karl Kieburtz (5) , Brit Mollenhauer (6) , Douglas Galasko (7) , Kalpana Merchant (8) , Tatiana Foroud , Lana M Chahine (9) , Daniel Weintraub (3) , Cindy Casaceli (5) , Ray Dorsey (5) , Renee Wilson (5) , Margaret Herzog (10) , Nichole Daegele , Vanessa Arnedo (10) , Mark Frasier (10) , Todd Sherer (10) , Ken Marek , Samuel Frank (11) , Danna Jennings (12) , Tanya Simuni (1) , John Seibyl , Duygu Tosun-Turgut , Leslie Shaw , John Trojanowski , Andrew Singleton , Arthur Toga , Werner Poewe , Kathleen Poston , Sohini Chowdhury , Catherine Kopil , Kenneth Marek , Cynthia Casaceli , Sugi Mahes , John Seibyl , Christina Salerno , Arthur Toga , Karen Crawford , Paola Casalin , Giulia Malferrari , Mali Gani Weisz , Avi Orr-Urtreger , John Trojanowski , Leslie Shaw , Andrew Singleton , Thomas Montine , David Russell , Nabila Dahodwala , Werner Poewe , Nir Giladi , Stewart Factor , Penelope Hogarth , David Standaert , Robert Hauser , Joseph Jankovic , Marie Saint-Hilaire , Irene Richard , David Shprecher , Hubert Fernandez , Katrina Brockmann , Liana Rosenthal , Paolo Barone , Alberto Espay , Dominic Rowe , Karen Marder , Anthony Santiago , Susan Bressman , Shu-Ching Hu , Stuart Isaacson , Jean-Christophe Corvol (13, 14) , Javiar Ruiz Martinez , Eduardo Tolosa , Yen Tai , Marios Politis , Debra Smejdir , Linda Rees , Karen Williams , Farah Kausar , Karen Williams , Whitney Richardson , Diana Willeke , Shawnees Peacock , Beatrice Heim , Anat Mirelman , Barbara Sommerfeld , Alison Freed , Katrina Wakeman , Courtney Blair , Stephanie Guthrie , Leigh Harrell , Christine Hunter , Cathi-Ann Thomas , Raymond James , Grace Zimmerman , Victoria Brown , Jennifer Mule , Ella Hilt , Kori Ribb , Susan Ainscough , Misty Wethington , Madelaine Ranola , Helen Mejia Santana , Juliana Moreno , Deborah Raymond , Krista Speketer , Lisbeth Carvajal , Stephanie Carvalho (13) , Ioana Croitoru , Alicia Garrido , Laura Marie Payne , Veena Viswanth , Lawrence Severt , Maurizio Facheris , Holly Soares , Mark A Mintun , Jesse Cedarbaum , Peggy Taylor , Kevin Biglan , Emily Vandenbroucke , Zulfiqar Haider Sheikh , Baris Bingol , Tanya Fischer , Pablo Sardi , Remi Forrat , Alastair Reith , Jan Egebjerg , Gabrielle Ahlberg Hillert , Barbara Saba (15) , Chris Min , Robert Umek , Joe Mather , Susan de Santi , Anke Post , Frank Boess , Kirsten Taylor , Igor Grachev , Andreja Avbersek , Pierandrea Muglia , Kaplana Merchant , Johannes Tauscher
Christopher Coffey
  • Function : Author
  • PersonId : 1343381
Andrew Siderowf
  • Function : Author
  • PersonId : 1343382
Brit Mollenhauer
  • Function : Author
  • PersonId : 1343383
Tatiana Foroud
  • Function : Author
  • PersonId : 1343384
Lana M Chahine
  • Function : Author
  • PersonId : 1343385
Daniel Weintraub
  • Function : Author
  • PersonId : 1343386
Cindy Casaceli
  • Function : Author
  • PersonId : 1343387
Ray Dorsey
  • Function : Author
  • PersonId : 1343388
Renee Wilson
  • Function : Author
  • PersonId : 1343389
Nichole Daegele
  • Function : Author
  • PersonId : 1343390
Ken Marek
  • Function : Author
Samuel Frank
  • Function : Author
  • PersonId : 1343392
John Seibyl
  • Function : Author
Duygu Tosun-Turgut
  • Function : Author
Leslie Shaw
  • Function : Author
John Trojanowski
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Andrew Singleton
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Arthur Toga
  • Function : Author
Werner Poewe
  • Function : Author
Kathleen Poston
  • Function : Author
Sohini Chowdhury
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Catherine Kopil
  • Function : Author
Kenneth Marek
  • Function : Author
Cynthia Casaceli
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Sugi Mahes
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John Seibyl
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Christina Salerno
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Arthur Toga
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Karen Crawford
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Paola Casalin
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Giulia Malferrari
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Mali Gani Weisz
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Avi Orr-Urtreger
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John Trojanowski
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Leslie Shaw
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Andrew Singleton
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Thomas Montine
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David Russell
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Nabila Dahodwala
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Werner Poewe
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Nir Giladi
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Stewart Factor
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Penelope Hogarth
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David Standaert
  • Function : Author
Robert Hauser
  • Function : Author
Joseph Jankovic
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Marie Saint-Hilaire
  • Function : Author
Irene Richard
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David Shprecher
  • Function : Author
Hubert Fernandez
  • Function : Author
Katrina Brockmann
  • Function : Author
Liana Rosenthal
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Paolo Barone
  • Function : Author
Alberto Espay
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Dominic Rowe
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Karen Marder
  • Function : Author
Anthony Santiago
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Susan Bressman
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Shu-Ching Hu
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Stuart Isaacson
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Javiar Ruiz Martinez
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Eduardo Tolosa
  • Function : Author
Yen Tai
  • Function : Author
Marios Politis
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Debra Smejdir
  • Function : Author
Linda Rees
  • Function : Author
Karen Williams
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Farah Kausar
  • Function : Author
Karen Williams
  • Function : Author
Whitney Richardson
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Diana Willeke
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Shawnees Peacock
  • Function : Author
Beatrice Heim
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Anat Mirelman
  • Function : Author
Barbara Sommerfeld
  • Function : Author
Alison Freed
  • Function : Author
Katrina Wakeman
  • Function : Author
Courtney Blair
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Stephanie Guthrie
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Leigh Harrell
  • Function : Author
Christine Hunter
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Cathi-Ann Thomas
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Raymond James
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Grace Zimmerman
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Victoria Brown
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Jennifer Mule
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Ella Hilt
  • Function : Author
Kori Ribb
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Susan Ainscough
  • Function : Author
Misty Wethington
  • Function : Author
Madelaine Ranola
  • Function : Author
Helen Mejia Santana
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Juliana Moreno
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Deborah Raymond
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Krista Speketer
  • Function : Author
Lisbeth Carvajal
  • Function : Author
Ioana Croitoru
  • Function : Author
Alicia Garrido
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Laura Marie Payne
  • Function : Author
Veena Viswanth
  • Function : Author
Lawrence Severt
  • Function : Author
Maurizio Facheris
  • Function : Author
Holly Soares
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Mark A Mintun
  • Function : Author
Jesse Cedarbaum
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Peggy Taylor
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Kevin Biglan
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Emily Vandenbroucke
  • Function : Author
Zulfiqar Haider Sheikh
  • Function : Author
Baris Bingol
  • Function : Author
Tanya Fischer
  • Function : Author
Pablo Sardi
  • Function : Author
Remi Forrat
  • Function : Author
Alastair Reith
  • Function : Author
Jan Egebjerg
  • Function : Author
Gabrielle Ahlberg Hillert
  • Function : Author
Chris Min
  • Function : Author
Robert Umek
  • Function : Author
Joe Mather
  • Function : Author
Susan de Santi
  • Function : Author
Anke Post
  • Function : Author
Frank Boess
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Kirsten Taylor
  • Function : Author
Igor Grachev
  • Function : Author
Andreja Avbersek
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Pierandrea Muglia
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Kaplana Merchant
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Johannes Tauscher
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Abstract

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC). Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants. Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. All PPMI participants undergo LP at baseline, 6, 12 months and yearly thereafter. CSF collection is performed by a trained investigator using predominantly atraumatic needles. Adverse events (AEs) are monitored by phone one week after LP completion. We analyzed safety data from baseline LPs. Results: PPMI enrolled 683 participants (423 PD/196 HC/64 SWEDDs) from 23 study sites. CSF was collected at baseline in 97.5% of participants, of whom 5.4% underwent collection under fluoroscopy. 23% participants reported any related AEs, 68% of all AE were mild while 5.6% were severe. The most common AEs were headaches (13%) and low back pain (6.5%) and both occurred more commonly in HC and SWEDDs compared to PD participants. Factors associated with higher incidence of AEs across the cohorts included female gender, younger age and use of traumatic needles with larger diameter. AEs largely did not impact compliance with the future LPs. Conclusions: LPs are safe and feasible in PD research participants. Specific LP techniques (needle type and gauge) may reduce the overall incidence of AEs.

Dates and versions

hal-04423774 , version 1 (29-01-2024)

Identifiers

Cite

Neha Prakash, Chelsea Caspell-Garcia, Christopher Coffey, Andrew Siderowf, Caroline M Tanner, et al.. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI). Parkinsonism & Related Disorders, 2019, 62, pp.201-209. ⟨10.1016/j.parkreldis.2018.12.025⟩. ⟨hal-04423774⟩
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