Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study
Mikael Cohen
(1, 2)
,
Océane Thomel-Rocchi
(2)
,
Aksel Siva
(3)
,
Darin Okuda
(4)
,
Rana Karabudak
(5)
,
Hüsnü Efendi
(6)
,
Murat Terzi
(7)
,
Clarisse Carra-Dalliere
(8)
,
Francoise Durand-Dubief
(9)
,
Eric Thouvenot
(10)
,
Jonathan Ciron
(11, 12)
,
Helene Zephir
(13)
,
Bertrand Bourre
(14)
,
Olivier Casez
(15, 16)
,
Jérôme de Sèze
(17)
,
Thibault Moreau
(18)
,
Jean-Philippe Neau
(19)
,
Daniel Pelletier
(20)
,
Orhun Kantarci
(21)
,
Melih Tutuncu
(3)
,
Nathalie Derache
(22)
,
Caroline Bensa
(23)
,
Celine Louapre
(24)
,
Jeanne Benoit
(1, 2)
,
Cassandre Landes-Chateau
(1, 2)
,
Christine Lebrun-Frenay
(1, 2)
,
Christina Azevedo
(20)
,
Naila Makhani
(25)
,
Sedat Şen
(7)
,
Ugur Uygunoglu
(3)
1
URRIS UR2CA -
Unité de Recherche Clinique de la Côte d’Azur
2 Service de Neurologie [CHU Nice]
3 Cerrahpasa Faculty of Medicine
4 University of Texas Southwestern Medical Center [Dallas]
5 Faculty of Medicine [Hacettepe University]
6 Kocaeli University [Turkey]
7 OMU - Ondokuz Mayis University
8 Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier]
9 Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL]
10 IGF MGX - Institut de Génomique Fonctionnelle - Montpellier GenomiX
11 Département Neurologie [CHU Toulouse]
12 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
13 LilNCog - Lille Neurosciences & Cognition - U 1172
14 CHU Rouen
15 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
16 TIMC-T-RAIG - Translational Research in Autoimmunity and Inflammation Group
17 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
18 Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)
19 Service de neurologie [Poitiers]
20 USC - University of Southern California
21 Mayo Clinic [Rochester]
22 Service de Neurologie [CHU Caen]
23 Service de neurologie [Hôpital Fondation Adolphe de Rothschild]
24 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
25 Yale University [New Haven]
2 Service de Neurologie [CHU Nice]
3 Cerrahpasa Faculty of Medicine
4 University of Texas Southwestern Medical Center [Dallas]
5 Faculty of Medicine [Hacettepe University]
6 Kocaeli University [Turkey]
7 OMU - Ondokuz Mayis University
8 Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier]
9 Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL]
10 IGF MGX - Institut de Génomique Fonctionnelle - Montpellier GenomiX
11 Département Neurologie [CHU Toulouse]
12 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
13 LilNCog - Lille Neurosciences & Cognition - U 1172
14 CHU Rouen
15 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
16 TIMC-T-RAIG - Translational Research in Autoimmunity and Inflammation Group
17 Centre d’Investigation Clinique Plurithématique (CIC - P) - CIC Strasbourg
18 Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon)
19 Service de neurologie [Poitiers]
20 USC - University of Southern California
21 Mayo Clinic [Rochester]
22 Service de Neurologie [CHU Caen]
23 Service de neurologie [Hôpital Fondation Adolphe de Rothschild]
24 CIC Neurosciences - Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière]
25 Yale University [New Haven]
Mikael Cohen
- Fonction : Auteur
- PersonId : 755337
- ORCID : 0000-0002-3985-1297
- IdRef : 14074116X
Aksel Siva
- Fonction : Auteur
- PersonId : 1364616
- ORCID : 0000-0002-8340-6641
Darin Okuda
- Fonction : Auteur
- PersonId : 1235106
- ORCID : 0000-0002-6499-1523
Clarisse Carra-Dalliere
- Fonction : Auteur
- PersonId : 781230
- ORCID : 0000-0002-0985-3662
Francoise Durand-Dubief
- Fonction : Auteur
- PersonId : 172702
- IdHAL : francoise-durand-dubief
- ORCID : 0000-0002-2860-1700
- IdRef : 15778911X
Eric Thouvenot
- Fonction : Auteur
- PersonId : 1037455
- IdHAL : ericthouvenot
- ORCID : 0000-0001-8671-7747
- IdRef : 094970920
Jonathan Ciron
- Fonction : Auteur
- PersonId : 795646
- ORCID : 0000-0002-3386-6308
- IdRef : 137599021
Helene Zephir
- Fonction : Auteur
- PersonId : 1297076
- ORCID : 0000-0003-4029-2012
- IdRef : 081106475
Thibault Moreau
- Fonction : Auteur
- PersonId : 1403407
- ORCID : 0009-0001-1130-7214
Christine Lebrun-Frenay
- Fonction : Auteur
- PersonId : 770285
- ORCID : 0000-0002-3713-2416
- IdRef : 074517929
Christina Azevedo
- Fonction : Auteur
- PersonId : 1414740
- ORCID : 0000-0002-8622-1845
Naila Makhani
- Fonction : Auteur
- PersonId : 786682
- ORCID : 0000-0002-2325-130X
Résumé
Background: Vaccination in patients with multiple sclerosis (MS) treated with immunosuppressive drugs is highly recommended. Regarding COVID-19 vaccination, no specific concern has been raised. Objectives: We aimed to evaluate if COVID-19 vaccination or infection increased the risk of disease activity, either radiological or clinical, with conversion to MS in a cohort of people with a radiologically isolated syndrome (RIS). Methods: This multicentric observational study analyzed patients in the RIS Consortium cohort during the pandemic between January 2020 and December 2022. We compared the occurrence of disease activity in patients according to their vaccination status. The same analysis was conducted by comparing patients’ history of COVID-19 infection. Results: No difference was found concerning clinical conversion to MS in the vaccinated versus unvaccinated group (6.7% vs 8.5%, p > 0.9). The rate of disease activity was not statistically different (13.6% and 7.4%, respectively, p = 0.54). The clinical conversion rate to MS was not significantly different in patients with a documented COVID-19 infection versus non-infected patients. Conclusion: Our study suggests that COVID-19 infection or immunization in RIS individuals does not increase the risk of disease activity. Our results support that COVID-19 vaccination can be safely proposed and repeated for these subjects.