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Journal Articles Multiple Sclerosis Journal Year : 2023

Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study

Océane Thomel-Rocchi
  • Function : Author
Aksel Siva
Darin Okuda
Rana Karabudak
  • Function : Author
Hüsnü Efendi
  • Function : Author
Murat Terzi
  • Function : Author
Clarisse Carra-Dalliere
Francoise Durand-Dubief
Eric Thouvenot
Jonathan Ciron
Helene Zephir
  • Function : Author
Bertrand Bourre
  • Function : Author
Olivier Casez
  • Function : Author
Jérôme de Seze
  • Function : Author
Thibault Moreau
  • Function : Author
Jean-Philippe Neau
  • Function : Author
Daniel Pelletier
  • Function : Author
Orhun Kantarci
  • Function : Author
Melih Tutuncu
  • Function : Author
Nathalie Derache
  • Function : Author
Christine Lebrun-Frenay
  • Function : Author
Orhun Kantarci
  • Function : Author
Aksel Siva
  • Function : Author
Daniel Pelletier
  • Function : Author
Christina J Azevedo
  • Function : Author
Naila Makhani
  • Function : Author
Darin T Okuda
  • Function : Author
Rana Karabudak
  • Function : Author
Hüsnü Efendi
  • Function : Author
Sedat Şen
  • Function : Author
Murat Terzi
  • Function : Author
Ugur Uygunoglu
  • Function : Author
Melih Tutuncu
  • Function : Author
Aksel Siva
  • Function : Author

Abstract

Background: Vaccination in patients with multiple sclerosis (MS) treated with immunosuppressive drugs is highly recommended. Regarding COVID-19 vaccination, no specific concern has been raised. Objectives: We aimed to evaluate if COVID-19 vaccination or infection increased the risk of disease activity, either radiological or clinical, with conversion to MS in a cohort of people with a radiologically isolated syndrome (RIS). Methods: This multicentric observational study analyzed patients in the RIS Consortium cohort during the pandemic between January 2020 and December 2022. We compared the occurrence of disease activity in patients according to their vaccination status. The same analysis was conducted by comparing patients’ history of COVID-19 infection. Results: No difference was found concerning clinical conversion to MS in the vaccinated versus unvaccinated group (6.7% vs 8.5%, p > 0.9). The rate of disease activity was not statistically different (13.6% and 7.4%, respectively, p = 0.54). The clinical conversion rate to MS was not significantly different in patients with a documented COVID-19 infection versus non-infected patients. Conclusion: Our study suggests that COVID-19 infection or immunization in RIS individuals does not increase the risk of disease activity. Our results support that COVID-19 vaccination can be safely proposed and repeated for these subjects.

Dates and versions

hal-04508953 , version 1 (18-03-2024)

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Cite

Mikael Cohen, Océane Thomel-Rocchi, Aksel Siva, Darin Okuda, Rana Karabudak, et al.. Impact of COVID-19 vaccination or infection on disease activity in a radiologically isolated syndrome cohort: The VaxiRIS study. Multiple Sclerosis Journal, 2023, 29 (9), pp.1099-1106. ⟨10.1177/13524585231179669⟩. ⟨hal-04508953⟩
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