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Journal Articles Molecular Psychiatry Year : 2019

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Dmitry Isaev
  • Function : Author
Lyubomir I Aftanas
  • Function : Author
Ivan V Brak
Kathryn R Cullen
  • Function : Author
Konstantin V Danilenko
  • Function : Author
Elena Filimonova
  • Function : Author
Ian H Gotlib
  • Function : Author
Mathew A Harris
Ian B Hickie
  • Function : Author
Tiffany C Ho
  • Function : Author
Andreas Jansen
  • Function : Author
Tilo Kircher
  • Function : Author
Bonnie Klimes-Dougan
  • Function : Author
Peter Kochunov
  • Function : Author
Axel Krug
  • Function : Author
Jim Lagopoulos
  • Function : Author
Renick Lee
  • Function : Author
Tristram A Lett
Meng Li
  • Function : Author
Frank P Macmaster
  • Function : Author
Nicholas G Martin
Andrew M Mcintosh
Quinn Mclellan
Susanne Meinert
  • Function : Author
Igor Nenadić
  • Function : Author
Evgeny Osipov
  • Function : Author
Brenda W J H Penninx
  • Function : Author
Maria J Portella
  • Function : Author
Jonathan Repple
  • Function : Author
Annerine Roos
  • Function : Author
Matthew D Sacchet
  • Function : Author
Philipp G Sämann
  • Function : Author
Knut Schnell
  • Function : Author
Xueyi Shen
  • Function : Author
Kang Sim
  • Function : Author
Dan J Stein
Marie-Jose van Tol
Alexander S Tomyshev
  • Function : Author
Leonardo Tozzi
  • Function : Author
Ilya M Veer
  • Function : Author
Robert Vermeiren
  • Function : Author
Yolanda Vives-Gilabert
  • Function : Author
Henrik Walter
Martin Walter
  • Function : Author
Nic J A van der Wee
  • Function : Author
Steven J A van der Werff
  • Function : Author
Melinda Westlund Schreiner
Heather C Whalley
Margaret J Wright
Tony T Yang
  • Function : Author
Alyssa Zhu
  • Function : Author
Dick J Veltman
  • Function : Author
Paul M Thompson
  • Function : Author
Neda Jahanshad
Lianne Schmaal
  • Function : Author

Abstract

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen’s d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen’s d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
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Dates and versions

hal-04512469 , version 1 (20-03-2024)

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Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir I Aftanas, et al.. White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Molecular Psychiatry, 2019, 25, pp.1511 - 1525. ⟨10.1038/s41380-019-0477-2⟩. ⟨hal-04512469⟩
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