White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Laura S van Velzen; Sinead Kelly; Dmitry Isaev; Andre Aleman; Lyubomir I Aftanas; Jochen Bauer; Bernhard T Baune; Ivan V Brak; Angela Carballedo; Colm G Connolly; Baptiste Couvy-Duchesne; Kathryn R Cullen; Konstantin V Danilenko; Udo Dannlowski; Verena Enneking; Elena Filimonova; Katharina Förster; Thomas Frodl; Ian H Gotlib; Nynke A Groenewold; Dominik Grotegerd; Mathew A Harris; Sean N Hatton; Emma L Hawkins; Ian B Hickie; Tiffany C Ho; Andreas Jansen; Tilo Kircher; Bonnie Klimes-Dougan; Peter Kochunov; Axel Krug; Jim Lagopoulos; Renick Lee; Tristram A Lett; Meng Li; Frank P Macmaster; Nicholas G Martin; Andrew M Mcintosh; Quinn Mclellan; Susanne Meinert; Igor Nenadić; Evgeny Osipov; Brenda W J H Penninx; Maria J Portella; Jonathan Repple; Annerine Roos; Matthew D Sacchet; Philipp G Sämann; Knut Schnell; Xueyi Shen; Kang Sim; Dan J Stein; Marie-Jose van Tol; Alexander S Tomyshev; Leonardo Tozzi; Ilya M Veer; Robert Vermeiren; Yolanda Vives-Gilabert; Henrik Walter; Martin Walter; Nic J A van der Wee; Steven J A van der Werff; Melinda Westlund Schreiner; Heather C Whalley; Margaret J Wright; Tony T Yang; Alyssa Zhu; Dick J Veltman; Paul M Thompson; Neda Jahanshad; Lianne Schmaal

doi:10.1038/s41380-019-0477-2

Journal Articles Molecular Psychiatry Year : 2019

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

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Laura S van Velzen

Function : Author
PersonId : 1365375

Amsterdam University Medical Centers

University of Melbourne

Sinead Kelly

Function : Author

Harvard Medical School [Boston]

Dmitry Isaev

Function : Author

Andre Aleman

Function : Author

University of Groningen [Groningen]

Lyubomir I Aftanas

Function : Author

Jochen Bauer

Function : Author

Westfälische Wilhelms-Universität Münster = University of Münster

Bernhard T Baune

Function : Author
PersonId : 804018
ORCID : 0000-0001-6548-426X

Westfälische Wilhelms-Universität Münster = University of Münster

University of Melbourne

Ivan V Brak

Function : Author
PersonId : 1358213
ORCID : 0000-0002-5146-0096

Angela Carballedo

Function : Author

Trinity College Dublin

Colm G Connolly

Function : Author
PersonId : 1210796
ORCID : 0000-0002-4051-3682

University of California [San Francisco]

Baptiste Couvy-Duchesne

Function : Author
PersonId : 739328
IdHAL : baptiste-couvy-duchesne
ORCID : 0000-0002-0719-9302

Institut du Cerveau = Paris Brain Institute

Kathryn R Cullen

Function : Author

Konstantin V Danilenko

Function : Author

Udo Dannlowski

Function : Author

Westfälische Wilhelms-Universität Münster = University of Münster

Verena Enneking

Function : Author

Westfälische Wilhelms-Universität Münster = University of Münster

Elena Filimonova

Function : Author

Katharina Förster

Function : Author

Westfälische Wilhelms-Universität Münster = University of Münster

Thomas Frodl

Function : Author

Trinity College Dublin

Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]

Ian H Gotlib

Function : Author

Stanford University

Nynke A Groenewold

Function : Author

University of Cape Town

Dominik Grotegerd

Function : Author

Westfälische Wilhelms-Universität Münster = University of Münster

Mathew A Harris

Function : Author
PersonId : 1356000
ORCID : 0000-0002-1135-4141

University of Edinburgh

Sean N Hatton

Function : Author

The University of Sydney

Emma L Hawkins

Function : Author

University of Edinburgh

Ian B Hickie

Function : Author

Tiffany C Ho

Function : Author

Andreas Jansen

Function : Author

Tilo Kircher

Function : Author

Bonnie Klimes-Dougan

Function : Author

Peter Kochunov

Function : Author

Axel Krug

Function : Author

Jim Lagopoulos

Function : Author

Renick Lee

Function : Author

Tristram A Lett

Function : Author
PersonId : 1355369
ORCID : 0000-0002-0731-9626

Meng Li

Function : Author

Frank P Macmaster

Function : Author

Nicholas G Martin

Function : Author
PersonId : 1188333
ORCID : 0000-0003-4069-8020

Andrew M Mcintosh

Function : Author
PersonId : 1178325
ORCID : 0000-0002-0198-4588

Quinn Mclellan

Function : Author
PersonId : 1365376
ORCID : 0000-0003-3806-2218

Susanne Meinert

Function : Author

Igor Nenadić

Function : Author

Evgeny Osipov

Function : Author

Brenda W J H Penninx

Function : Author

Maria J Portella

Function : Author

Jonathan Repple

Function : Author

Annerine Roos

Function : Author

Matthew D Sacchet

Function : Author

Philipp G Sämann

Function : Author

Knut Schnell

Function : Author

Xueyi Shen

Function : Author

Kang Sim

Function : Author

Dan J Stein

Function : Author
PersonId : 792751
ORCID : 0000-0001-7218-7810
IdRef : 033376417

Marie-Jose van Tol

Function : Author
PersonId : 1358218
ORCID : 0000-0002-9260-5490

Alexander S Tomyshev

Function : Author

Leonardo Tozzi

Function : Author

Ilya M Veer

Function : Author

Robert Vermeiren

Function : Author

Yolanda Vives-Gilabert

Function : Author

Henrik Walter

Function : Author
PersonId : 1354965
ORCID : 0000-0002-9403-6121

Martin Walter

Function : Author

Nic J A van der Wee

Function : Author

Steven J A van der Werff

Function : Author

Melinda Westlund Schreiner

Function : Author
PersonId : 1365377
ORCID : 0000-0002-2780-3327

Heather C Whalley

Function : Author
PersonId : 1358219
ORCID : 0000-0002-4505-8869

Margaret J Wright

Function : Author
PersonId : 1188332
ORCID : 0000-0001-7133-4970

Tony T Yang

Function : Author

Alyssa Zhu

Function : Author

Dick J Veltman

Function : Author

Paul M Thompson

Function : Author

Neda Jahanshad

Function : Author
PersonId : 1192274
ORCID : 0000-0003-4401-8950

Lianne Schmaal

Function : Author

Abstract

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen’s d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen’s d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.

Domains

Human health and pathology

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https://hal.sorbonne-universite.fr/hal-04512469

Submitted on : Wednesday, March 20, 2024-9:26:24 AM

Last modification on : Friday, December 6, 2024-2:22:03 PM

Long-term archiving on : Monday, June 24, 2024-9:11:17 AM

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hal-04512469 , version 1 (20-03-2024)

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HAL Id : hal-04512469 , version 1
DOI : 10.1038/s41380-019-0477-2

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Laura S van Velzen, Sinead Kelly, Dmitry Isaev, Andre Aleman, Lyubomir I Aftanas, et al.. White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group. Molecular Psychiatry, 2019, 25, pp.1511 - 1525. ⟨10.1038/s41380-019-0477-2⟩. ⟨hal-04512469⟩

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White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

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