Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia - Sorbonne Université Access content directly
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2018

Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Efthimios Dardiotis
  • Function : Author
Paul Maruff
  • Function : Author

Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E ε4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts.
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Dates and versions

hal-04517595 , version 1 (22-03-2024)

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Rosalinde Slot, Sietske Sikkes, Johannes Berkhof, Henry Brodaty, Rachel Buckley, et al.. Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 15 (3), pp.465-476. ⟨10.1016/j.jalz.2018.10.003⟩. ⟨hal-04517595⟩
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