Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes - Sorbonne Université Access content directly
Journal Articles Revue Neurologique Year : 2023

Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes


Background and purpose: Mechanisms underlying acute brain injury in SARS-CoV-2 patients remain poorly understood. A better characterization of such mechanisms remains essential to preventing long-term neurological sequelae. Our present aim was to study a panel of biomarkers of neuroinflammation and neurodegeneration in the cerebrospinal fluid (CSF) of NeuroCOVID patients. Methods: We retrospectively collected clinical and CSF biomarkers data from 24 NeuroCOVID adults seen at the University Hospital of Guadeloupe between March and June 2021. Results: Among 24 NeuroCOVID patients, 71% had encephalopathy and 29% meningoencephalitis. A number of these patients also experienced de novo movement disorder (33%) or stroke (21%). The CSF analysis revealed intrathecal immunoglobulin synthesis in 54% of NeuroCOVID patients (two with a type 2 pattern and 11 with a type 3) and elevated neopterin levels in 75% of them (median 9.1nM, IQR 5.6-22.1). CSF neurofilament light chain (NfL) was also increased compared to a control group of non-COVID-19 patients with psychiatric illnesses (2905ng/L, IQR 1428-7124 versus 1222ng/L, IQR 1049-1566). Total-tau was elevated in the CSF of 24% of patients, whereas protein 14-3-3, generally undetectable, reached intermediate levels in two patients. Finally, CSF Aß1-42 was reduced in 52.4% of patients (median 536ng/L, IQR 432-904) with no change in the Aß1-42/Aß1-40 ratio (0.082, IQR 0.060-0.096). Conclusions: We showed an elevation of CSF biomarkers of neuroinflammation in NeuroCOVID patients and a rise of CSF NfL, evocative of neuronal damage. However, longitudinal studies are needed to determine whether NeuroCOVID could evolve into a chronic neurodegenerative condition.
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hal-04531399 , version 1 (03-04-2024)



H. Chaumont, F. Kaczorowski, A. San-Galli, P.P. Michel, B. Tressières, et al.. Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes. Revue Neurologique, 2023, 179 (3), pp.208-217. ⟨10.1016/j.neurol.2022.11.002⟩. ⟨hal-04531399⟩
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