Objectives: To assess the benefit of surgical management of patients with endometriosis infiltrating pelvic nerves in terms of pain, analgesic consumption, and quality of life (QOL). Methods: We conducted a retrospective cohort study In an Endometriosis referral center at a tertiary care university affiliated medical center. Patients diagnosed with endometriosis that underwent laparoscopic neurolysis for chronic pain were included. Patients rated their pain before and after surgery and differentiated between chronic pain and acute crises. Patients were requested to maintain a record of analgesic consumption and to evaluate their quality-of-life (QOL). Results: Of the 21 patients in our study 15 (71.5%) had obturator nerve involvement, 2 (9.5%) had pudendal nerve involvement and 4 (19%) had other pelvic nerve involvement. Median postoperative follow - up was of 8 months. All but 2 patients (9.6%) had significant chronic pain improvement with a mean decrease of VAS of 3.05 (±2.5). Analgesic habits changed postoperatively with a significant decrease of 66% of patients' daily consumption of any analgesics. Surgery improved QOL in 12 cases (57.1%) and two patients (9.6%) completely recovered with a high QOL. Conclusion: Neurolysis and excision of endometriosis of pelvic nerves could results in significant improvement of quality of life.