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Journal Articles Neuron Year : 2019

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Frank Koopmans (1, 2) , Pim van Nierop (1, 2) , Maria Andres-Alonso (3) , Andrea Byrnes (4) , Tony Cijsouw (5) , Marcelo Coba (6) , L Niels Cornelisse (1, 2) , Ryan Farrell (1, 2) , Hana Goldschmidt (7) , Daniel Howrigan (4) , Natasha Hussain (4) , Cordelia Imig (8) , Arthur de Jong (9) , Hwajin Jung (10) , Mahdokht Kohansalnodehi (7) , Barbara Kramarz (11) , Noa Lipstein (8) , Ruth Lovering (12) , Harold Macgillavry (13) , Vittoria Mariano (14, 15) , Huaiyu Mi (6) , Momchil Ninov (16) , David Osumi-Sutherland , Rainer Pielot (3) , Karl-Heinz Smalla (3) , Haiming Tang (6) , Katherine Tashman (4) , Ruud Toonen (1, 2) , Chiara Verpelli (14, 15) , Rita Reig-Viader (17) , Kyoko Watanabe (18, 2) , Jan van Weering (2, 1) , Tilmann Achsel (14, 15) , Ghazaleh Ashrafi (19) , Nimra Asi (4, 8) , Tyler Brown (4) , Pietro de Camilli (20) , Marc Feuermann (21) , Rebecca Foulger (12) , Pascale Gaudet (21) , Anoushka Joglekar (19) , Alexandros Kanellopoulos (14) , Robert Malenka (22) , Roger Nicoll (23) , Camila Pulido (19) , Jaime de Juan-Sanz (19, 24) , Morgan Sheng , Thomas Südhof , Hagen Tilgner , Claudia Bagni , Àlex Bayés , Thomas Biederer , Nils Brose , John Jia En Chua , Daniela Dieterich , Eckart Gundelfinger , Casper Hoogenraad , Richard Huganir , Reinhard Jahn , Pascal Kaeser , Eunjoon Kim , Michael Kreutz , Peter Mcpherson , Ben Neale , Vincent O'Connor , Danielle Posthuma , Timothy Ryan , Carlo Sala , Guoping Feng , Steven Hyman , Paul Thomas , August Smit , Matthijs Verhage , L. Niels Cornelisse , Arthur P.H. de Jong , Ruud F.G. Toonen , Vincent O’connor
David Osumi-Sutherland
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Morgan Sheng
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Thomas Südhof
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Hagen Tilgner
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Claudia Bagni
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Àlex Bayés
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Thomas Biederer
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Nils Brose
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John Jia En Chua
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Daniela Dieterich
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Eckart Gundelfinger
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Casper Hoogenraad
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Richard Huganir
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Reinhard Jahn
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Pascal Kaeser
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Eunjoon Kim
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Michael Kreutz
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Peter Mcpherson
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Ben Neale
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Vincent O'Connor
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Danielle Posthuma
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Timothy Ryan
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Carlo Sala
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Guoping Feng
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Steven Hyman
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Paul Thomas
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August Smit
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Matthijs Verhage
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L. Niels Cornelisse
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Arthur P.H. de Jong
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Ruud F.G. Toonen
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Vincent O’connor
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Abstract

Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with intelligence, educational attainment, ADHD, autism, and bipolar disorder and among de novo variants associated with neurodevelopmental disorders, including schizophrenia. SynGO is a public, universal reference for synapse research and an online analysis platform for interpretation of large-scale -omics data (https://syngoportal.org and http://geneontology.org).

Dates and versions

hal-04560138 , version 1 (26-04-2024)

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Frank Koopmans, Pim van Nierop, Maria Andres-Alonso, Andrea Byrnes, Tony Cijsouw, et al.. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron, 2019, 103 (2), pp.217-234.e4. ⟨10.1016/j.neuron.2019.05.002⟩. ⟨hal-04560138⟩
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