Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders - Sorbonne Université Access content directly
Journal Articles Cell Year : 2019

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee (1) , Verneri Anttila (2) , Hyejung Won (3) , Yen-Chen Feng , Jacob Rosenthal , Zhaozhong Zhu , Elliot Tucker-Drob , Michel Nivard , Andrew Grotzinger , Danielle Posthuma (4) , Meg M.-J. Wang , Dongmei Yu (2, 5) , Eli Stahl (6) , Raymond Walters (2, 7, 5) , Richard J.L. Anney , Laramie Duncan (2) , Tian Ge (8) , Rolf Adolfsson , Tobias Banaschewski (9, 10) , Sintia Belangero , Edwin Cook , Giovanni Coppola , Eske Derks , Pieter Hoekstra , Jaakko Kaprio , Anna Keski-Rahkonen , George Kirov , Henry Kranzler , Jurjen Luykx , Luis Rohde , Clement Zai , Esben Agerbo , M.J. Arranz , Philip Asherson , Marie Bækvad-Hansen , Gísli Baldursson , Mark Bellgrove , Richard Belliveau , Jan Buitelaar , Christie Burton , Jonas Bybjerg-Grauholm , Miquel Casas , Felecia Cerrato , Kimberly Chambert , Claire Churchhouse , Bru Cormand , Jennifer Crosbie , Søren Dalsgaard , Ditte Demontis , Alysa Doyle , Ashley Dumont , Josephine Elia , Jakob Grove , Olafur Gudmundsson , Jan Haavik , Hakon Hakonarson , Christine Hansen , Catharina Hartman , Ziarih Hawi , Amaia Hervás , David Hougaard , Daniel Howrigan , Hailiang Huang , Jonna Kuntsi , Kate Langley , Klaus-Peter Lesch , Patrick W.L. Leung , Sandra Loo , Joanna Martin , Alicia Martin , James Mcgough , Sarah Medland , Jennifer Moran , Ole Mors , Preben Mortensen , Robert Oades , Duncan Palmer , Carsten Pedersen , Marianne Pedersen , Triinu Peters , Timothy Poterba , Jesper Poulsen , Josep Antoni Ramos-Quiroga , Andreas Reif , Marta Ribasés , Aribert Rothenberger , Paula Rovira , Cristina Sánchez-Mora , F. Kyle Satterstrom , Russell Schachar , Maria Soler Artigas , Stacy Steinberg , Hreinn Stefansson , Patrick Turley , G. Bragi Walters , Thomas Werge , Tetyana Zayats , Dan Arking , Francesco Bettella , Joseph Buxbaum , Jane Christensen , Ryan Collins , Hilary Coon , Silvia De Rubeis , Richard Delorme , Dorothy Grice , Thomas Hansen , Peter Holmans , Sigrun Hope , Christina Hultman , Lambertus Klei , Christine Ladd-Acosta , Pall Magnusson , Terje Nærland , Mette Nyegaard , Dalila Pinto , Per Qvist , Karola Rehnström , Abraham Reichenberg , Jennifer Reichert , Kathryn Roeder , Guy Rouleau , Evald Saemundsen , Stephan Sanders , Sven Sandin , Beate St Pourcain , Kari Stefansson , James Sutcliffe , Michael Talkowski , Lauren Weiss , A. Jeremy Willsey , Ingrid Agartz , Huda Akil , Diego Albani , Martin Alda , Thomas Als , Adebayo Anjorin , Lena Backlund , Nicholas Bass , Michael Bauer , Bernhard Baune , Frank Bellivier , Sarah Bergen , Wade Berrettini , Joanna Biernacka , Douglas H.R. Blackwood , Erlend Bøen , Monika Budde , William Bunney , Margit Burmeister , William Byerley , Enda Byrne , Sven Cichon , Toni-Kim Clarke , Jonathan R.I. Coleman , Nicholas Craddock , David Curtis , Piotr Czerski , Anders Dale , Nina Dalkner , Udo Dannlowski , Franziska Degenhardt , Arianna Di Florio , Torbjørn Elvsåshagen , Bruno Etain , Sascha Fischer , Andreas Forstner , Liz Forty , Josef Frank , Mark Frye , Janice Fullerton , Katrin Gade , Héléna Gaspar , Elliot Gershon , Michael Gill , Fernando Goes , Scott Gordon , Katherine Gordon-Smith , Melissa Green , Tiffany Greenwood , Maria Grigoroiu-Serbanescu , José Guzman-Parra , Joanna Hauser , Martin Hautzinger , Urs Heilbronner , Stefan Herms , Per Hoffmann , Dominic Holland , Stéphane Jamain , Ian Jones , Lisa Jones , Radhika Kandaswamy , John Kelsoe , James Kennedy , Oedegaard Ketil Joachim , Sarah Kittel-Schneider , Manolis Kogevinas , Anna Koller , Catharina Lavebratt , Cathryn Lewis , Qingqin Li , Jolanta Lissowska , Loes M.O. Loohuis , Susanne Lucae , Anna Maaser , Ulrik Malt , Nicholas Martin , Lina Martinsson , Susan Mcelroy , Francis Mcmahon , Andrew Mcquillin , Ingrid Melle , Andres Metspalu , Vincent Millischer , Philip Mitchell , Grant Montgomery , Gunnar Morken , Derek Morris , Bertram Müller-Myhsok , Niamh Mullins , Richard Myers , Caroline Nievergelt , Merete Nordentoft , Annelie Nordin Adolfsson , Markus Nöthen , Roel Ophoff , Michael Owen , Sara Paciga , Carlos Pato , Michele Pato , Roy Perlis , Amy Perry , James Potash , Céline Reinbold , Marcella Rietschel , Margarita Rivera , Mary Roberson , Martin Schalling , Peter Schofield , Thomas Schulze , Laura Scott , Alessandro Serretti , Engilbert Sigurdsson , Olav Smeland , Eystein Stordal , Fabian Streit , Jana Strohmaier , Thorgeir Thorgeirsson , Jens Treutlein , Gustavo Turecki , Arne Vaaler , Eduard Vieta , John Vincent , Yunpeng Wang , Stephanie Witt , Peter Zandi , Roger A.H. Adan , Lars Alfredsson , Tetsuya Ando , Harald Aschauer , Jessica Baker , Vladimir Bencko , Andrew Bergen , Andreas Birgegård , Vesna Boraska Perica , Harry Brandt , Roland Burghardt , Laura Carlberg , Matteo Cassina , Maurizio Clementi , Philippe Courtet , Steven Crawford , Scott Crow , James Crowley , Unna Danner , Oliver S.P. Davis , Daniela Degortes , Janiece Desocio , Danielle Dick , Christian Dina , Elisa Docampo , Karin Egberts , Stefan Ehrlich , Thomas Espeseth , Fernando Fernández-Aranda , Manfred Fichter , Lenka Foretova , Monica Forzan , Giovanni Gambaro , Ina Giegling , Fragiskos Gonidakis , Philip Gorwood , Monica Gratacos Mayora , Yiran Guo , Katherine Halmi , Konstantinos Hatzikotoulas , Johannes Hebebrand , Sietske Helder , Beate Herpertz-Dahlmann , Wolfgang Herzog , Anke Hinney , Hartmut Imgart , Susana Jiménez-Murcia , Craig Johnson , Jennifer Jordan , Antonio Julià , Deborah Kaminská , Leila Karhunen , Andreas Karwautz , Martien J.H. Kas , Walter Kaye , Martin Kennedy , Youl-Ri Kim , Lars Klareskog , Kelly Klump , Gun Peggy S. Knudsen , Mikael Landén , Stephanie Le Hellard , Robert Levitan , Dong Li , Paul Lichtenstein , Mario Maj , Sara Marsal , Sara Mcdevitt , James Mitchell , Palmiero Monteleone , Alessio Maria Monteleone , Melissa Munn-Chernoff , Benedetta Nacmias , Marie Navratilova , Julie O’toole , Leonid Padyukov , Jacques Pantel , Hana Papezova , Raquel Rabionet , Anu Raevuori , Nicolas Ramoz , Ted Reichborn-Kjennerud , Valdo Ricca , Marion Roberts , Dan Rujescu , Filip Rybakowski , André Scherag , Ulrike Schmidt , Jochen Seitz , Lenka Slachtova , Agnieszka Slopien , Sandro Sorbi , Lorraine Southam , Michael Strober , Alfonso Tortorella , Federica Tozzi , Janet Treasure , Konstantinos Tziouvas , Annemarie van Elburg , Tracey Wade , Gudrun Wagner , Esther Walton , Hunna Watson , H-Erich Wichmann , D. Blake Woodside , Eleftheria Zeggini , Stephanie Zerwas , Stephan Zipfel , Mark Adams , Till F.M. Andlauer , Klaus Berger , Elisabeth Binder , Dorret Boomsma , Enrique Castelao , Lucía Colodro-Conde , Nese Direk , Anna Docherty , Enrico Domenici , Katharina Domschke , Erin Dunn , Jerome Foo , E.J.C. De. Geus , Hans Grabe , Steven Hamilton , Carsten Horn , Jouke-Jan Hottenga , David Howard , Marcus Ising , Stefan Kloiber , Douglas Levinson , Glyn Lewis , Patrik K.E. Magnusson , Hamdi Mbarek , Christel Middeldorp , Sara Mostafavi , Dale Nyholt , Brenda Wjh. Penninx , Roseann Peterson , Giorgio Pistis , David Porteous , Martin Preisig , Jorge Quiroz , Catherine Schaefer , Eva Schulte , Jianxin Shi , Daniel Smith , Pippa Thomson , Henning Tiemeier , Rudolf Uher , Sandra van der Auwera , Myrna Weissman , Madeline Alexander , Martin Begemann , Elvira Bramon , Nancy Buccola , Murray Cairns , Dominique Campion , Vaughan Carr , C. Robert Cloninger , David Cohen , David Collier , Aiden Corvin , Lynn Delisi , Gary Donohoe , Frank Dudbridge , Jubao Duan , Robert Freedman , Pablo Gejman , Vera Golimbet , Stephanie Godard , Hannelore Ehrenreich , Annette Hartmann (11) , Frans Henskens , Masashi Ikeda , Nakao Iwata , Assen Jablensky , Inge Joa , Erik Jönsson , Brian Kelly , Jo Knight , Bettina Konte , Claudine Laurent-Levinson , Jimmy Lee , Todd Lencz , Bernard Lerer , Carmel Loughland , Anil Malhotra , Jacques Mallet , Colm McDonald , Marina Mitjans , Bryan Mowry , Kieran Murphy , Robin Murray , F. Anthony O’neill , Sang-Yun Oh , Aarno Palotie , Christos Pantelis , Ann Pulver , Tracey Petryshen , Digby Quested , Brien Riley , Alan Sanders , Ulrich Schall , Sibylle Schwab , Rodney Scott , Pak Sham , Jeremy Silverman , Kang Sim , Agnes Steixner , Paul Tooney , Jim van Os , Marquis Vawter , Dermot Walsh , Mark Weiser , Dieter Wildenauer , Nigel Williams , Brandon Wormley , Fuquan Zhang , Christos Androutsos , Paul Arnold , Cathy Barr , Csaba Barta , Katharina Bey , O. Joseph Bienvenu , Donald Black , Lawrence Brown , Cathy Budman , Danielle Cath , Keun-Ah Cheon , Valentina Ciullo , Barbara Coffey , Daniele Cusi , Lea Davis , Damiaan Denys , Christel Depienne (11) , Andrea Dietrich , Valsamma Eapen , Peter Falkai , Thomas Fernandez , Blanca Garcia-Delgar , Daniel Geller , Donald Gilbert , Marco Grados , Erica Greenberg , Edna Grünblatt , Julie Hagstrøm , Gregory Hanna , Andreas Hartmann , Tammy Hedderly , Gary Heiman , Isobel Heyman , Hyun Ju Hong , Alden Huang , Chaim Huyser , Laura Ibanez-Gomez , Ekaterina Khramtsova , Young Key Kim , Young-Shin Kim , Robert King , Yun-Joo Koh , Anastasios Konstantinidis , Sodahm Kook , Samuel Kuperman , Bennett Leventhal , Christine Lochner , Andrea Ludolph , Marcos Madruga-Garrido , Irene Malaty , Athanasios Maras , James Mccracken , Inge Meijer , Pablo Mir , Astrid Morer , Kirsten Müller-Vahl , Alexander Münchau , Tara Murphy , Allan Naarden , Peter Nagy , Gerald Nestadt , Paul Nestadt , Humberto Nicolini , Erika Nurmi , Michael Okun , Peristera Paschou , Fabrizio Piras , Federica Piras , Christopher Pittenger , Kerstin Plessen , Margaret Richter , Renata Rizzo , Mary Robertson , Veit Roessner , Stephan Ruhrmann , Jack Samuels , Paul Sandor , Monika Schlögelhofer , Eun-Young Shin , Harvey Singer , Dong-Ho Song , Jungeun Song , Gianfranco Spalletta , Dan Stein , S Evelyn Stewart , Eric Storch , Barbara Stranger , Manfred Stuhrmann , Zsanett Tarnok , Jay Tischfield , Jennifer Tübing , Frank Visscher , Nienke Vulink , Michael Wagner , Susanne Walitza , Sina Wanderer , Martin Woods , Yulia Worbe , Gwyneth Zai , Samuel Zinner , Patrick Sullivan , Barbara Franke , Mark Daly , Cynthia Bulik , Cathryn Lewis , Andrew McIntosh , Michael O’donovan , Amanda Zheutlin , Ole Andreassen , Anders Børglum , Gerome Breen , Howard Edenberg , Ayman Fanous , Stephen Faraone , Joel Gelernter , Carol Mathews , Manuel Mattheisen , Karen Mitchell , Michael Neale , John Nurnberger , Stephan Ripke , Susan Santangelo , Jeremiah Scharf , Murray Stein , Laura Thornton , James T.R. Walters , Naomi Wray , Daniel Geschwind , Benjamin Neale , Kenneth Kendler , Jordan Smoller
Yen-Chen Feng
  • Function : Author
Jacob Rosenthal
  • Function : Author
Zhaozhong Zhu
  • Function : Author
Elliot Tucker-Drob
  • Function : Author
Michel Nivard
  • Function : Author
Andrew Grotzinger
  • Function : Author
Meg M.-J. Wang
  • Function : Author
Richard J.L. Anney
  • Function : Author
Rolf Adolfsson
  • Function : Author
Sintia Belangero
  • Function : Author
Edwin Cook
  • Function : Author
Giovanni Coppola
  • Function : Author
Eske Derks
  • Function : Author
Pieter Hoekstra
  • Function : Author
Jaakko Kaprio
  • Function : Author
Anna Keski-Rahkonen
  • Function : Author
George Kirov
  • Function : Author
Henry Kranzler
  • Function : Author
Jurjen Luykx
  • Function : Author
Luis Rohde
  • Function : Author
Clement Zai
  • Function : Author
Esben Agerbo
  • Function : Author
M.J. Arranz
  • Function : Author
Philip Asherson
  • Function : Author
Marie Bækvad-Hansen
  • Function : Author
Gísli Baldursson
  • Function : Author
Mark Bellgrove
  • Function : Author
Richard Belliveau
  • Function : Author
Jan Buitelaar
  • Function : Author
Christie Burton
  • Function : Author
Jonas Bybjerg-Grauholm
  • Function : Author
Miquel Casas
  • Function : Author
Felecia Cerrato
  • Function : Author
Kimberly Chambert
  • Function : Author
Claire Churchhouse
  • Function : Author
Bru Cormand
  • Function : Author
Jennifer Crosbie
  • Function : Author
Søren Dalsgaard
  • Function : Author
Ditte Demontis
  • Function : Author
Alysa Doyle
  • Function : Author
Ashley Dumont
  • Function : Author
Josephine Elia
  • Function : Author
Jakob Grove
  • Function : Author
Olafur Gudmundsson
  • Function : Author
Jan Haavik
  • Function : Author
Hakon Hakonarson
  • Function : Author
Christine Hansen
  • Function : Author
Catharina Hartman
  • Function : Author
Ziarih Hawi
  • Function : Author
Amaia Hervás
  • Function : Author
David Hougaard
  • Function : Author
Daniel Howrigan
  • Function : Author
Hailiang Huang
  • Function : Author
Jonna Kuntsi
  • Function : Author
Kate Langley
  • Function : Author
Klaus-Peter Lesch
  • Function : Author
Patrick W.L. Leung
  • Function : Author
Sandra Loo
  • Function : Author
Joanna Martin
  • Function : Author
Alicia Martin
  • Function : Author
James Mcgough
  • Function : Author
Sarah Medland
  • Function : Author
Jennifer Moran
  • Function : Author
Ole Mors
  • Function : Author
Preben Mortensen
  • Function : Author
Robert Oades
  • Function : Author
Duncan Palmer
  • Function : Author
Carsten Pedersen
  • Function : Author
Marianne Pedersen
  • Function : Author
Triinu Peters
  • Function : Author
Timothy Poterba
  • Function : Author
Jesper Poulsen
  • Function : Author
Josep Antoni Ramos-Quiroga
  • Function : Author
Andreas Reif
  • Function : Author
Marta Ribasés
  • Function : Author
Aribert Rothenberger
  • Function : Author
Paula Rovira
  • Function : Author
Cristina Sánchez-Mora
  • Function : Author
F. Kyle Satterstrom
  • Function : Author
Russell Schachar
  • Function : Author
Maria Soler Artigas
  • Function : Author
Stacy Steinberg
  • Function : Author
Hreinn Stefansson
  • Function : Author
Patrick Turley
  • Function : Author
G. Bragi Walters
  • Function : Author
Thomas Werge
  • Function : Author
Tetyana Zayats
  • Function : Author
Dan Arking
  • Function : Author
Francesco Bettella
  • Function : Author
Joseph Buxbaum
  • Function : Author
Jane Christensen
  • Function : Author
Ryan Collins
  • Function : Author
Hilary Coon
  • Function : Author
Silvia De Rubeis
  • Function : Author
Richard Delorme
  • Function : Author
Dorothy Grice
  • Function : Author
Thomas Hansen
  • Function : Author
Peter Holmans
  • Function : Author
Sigrun Hope
  • Function : Author
Christina Hultman
  • Function : Author
Lambertus Klei
  • Function : Author
Christine Ladd-Acosta
  • Function : Author
Pall Magnusson
  • Function : Author
Terje Nærland
  • Function : Author
Mette Nyegaard
  • Function : Author
Dalila Pinto
  • Function : Author
Per Qvist
  • Function : Author
Karola Rehnström
  • Function : Author
Abraham Reichenberg
  • Function : Author
Jennifer Reichert
  • Function : Author
Kathryn Roeder
  • Function : Author
Guy Rouleau
  • Function : Author
Evald Saemundsen
  • Function : Author
Stephan Sanders
  • Function : Author
Sven Sandin
  • Function : Author
Beate St Pourcain
  • Function : Author
Kari Stefansson
  • Function : Author
James Sutcliffe
  • Function : Author
Michael Talkowski
  • Function : Author
Lauren Weiss
  • Function : Author
A. Jeremy Willsey
  • Function : Author
Ingrid Agartz
  • Function : Author
Huda Akil
  • Function : Author
Diego Albani
  • Function : Author
Martin Alda
  • Function : Author
Thomas Als
  • Function : Author
Adebayo Anjorin
  • Function : Author
Lena Backlund
  • Function : Author
Nicholas Bass
  • Function : Author
Michael Bauer
  • Function : Author
Bernhard Baune
  • Function : Author
Frank Bellivier
  • Function : Author
Sarah Bergen
  • Function : Author
Wade Berrettini
  • Function : Author
Joanna Biernacka
  • Function : Author
Douglas H.R. Blackwood
  • Function : Author
Erlend Bøen
  • Function : Author
Monika Budde
  • Function : Author
William Bunney
  • Function : Author
Margit Burmeister
  • Function : Author
William Byerley
  • Function : Author
Enda Byrne
  • Function : Author
Sven Cichon
  • Function : Author
Toni-Kim Clarke
  • Function : Author
Jonathan R.I. Coleman
  • Function : Author
Nicholas Craddock
  • Function : Author
David Curtis
  • Function : Author
Piotr Czerski
  • Function : Author
Anders Dale
  • Function : Author
Nina Dalkner
  • Function : Author
Udo Dannlowski
  • Function : Author
Franziska Degenhardt
  • Function : Author
Arianna Di Florio
  • Function : Author
Torbjørn Elvsåshagen
  • Function : Author
Bruno Etain
  • Function : Author
Sascha Fischer
  • Function : Author
Andreas Forstner
  • Function : Author
Liz Forty
  • Function : Author
Josef Frank
  • Function : Author
Mark Frye
  • Function : Author
Janice Fullerton
  • Function : Author
Katrin Gade
  • Function : Author
Héléna Gaspar
  • Function : Author
Elliot Gershon
  • Function : Author
Michael Gill
  • Function : Author
Fernando Goes
  • Function : Author
Scott Gordon
  • Function : Author
Katherine Gordon-Smith
  • Function : Author
Melissa Green
  • Function : Author
Tiffany Greenwood
  • Function : Author
Maria Grigoroiu-Serbanescu
  • Function : Author
José Guzman-Parra
  • Function : Author
Joanna Hauser
  • Function : Author
Martin Hautzinger
  • Function : Author
Urs Heilbronner
  • Function : Author
Stefan Herms
  • Function : Author
Per Hoffmann
  • Function : Author
Dominic Holland
  • Function : Author
Stéphane Jamain
  • Function : Author
Ian Jones
  • Function : Author
Lisa Jones
  • Function : Author
Radhika Kandaswamy
  • Function : Author
John Kelsoe
  • Function : Author
James Kennedy
  • Function : Author
Oedegaard Ketil Joachim
  • Function : Author
Sarah Kittel-Schneider
  • Function : Author
Manolis Kogevinas
  • Function : Author
Anna Koller
  • Function : Author
Catharina Lavebratt
  • Function : Author
Cathryn Lewis
  • Function : Author
Qingqin Li
  • Function : Author
Jolanta Lissowska
  • Function : Author
Loes M.O. Loohuis
  • Function : Author
Susanne Lucae
  • Function : Author
Anna Maaser
  • Function : Author
Ulrik Malt
  • Function : Author
Nicholas Martin
  • Function : Author
Lina Martinsson
  • Function : Author
Susan Mcelroy
  • Function : Author
Francis Mcmahon
  • Function : Author
Andrew Mcquillin
  • Function : Author
Ingrid Melle
  • Function : Author
Andres Metspalu
  • Function : Author
Vincent Millischer
  • Function : Author
Philip Mitchell
  • Function : Author
Grant Montgomery
  • Function : Author
Gunnar Morken
  • Function : Author
Derek Morris
  • Function : Author
Bertram Müller-Myhsok
  • Function : Author
Niamh Mullins
  • Function : Author
Richard Myers
  • Function : Author
Caroline Nievergelt
  • Function : Author
Merete Nordentoft
  • Function : Author
Annelie Nordin Adolfsson
  • Function : Author
Markus Nöthen
  • Function : Author
Roel Ophoff
  • Function : Author
Michael Owen
  • Function : Author
Sara Paciga
  • Function : Author
Carlos Pato
  • Function : Author
Michele Pato
  • Function : Author
Roy Perlis
  • Function : Author
Amy Perry
  • Function : Author
James Potash
  • Function : Author
Céline Reinbold
  • Function : Author
Marcella Rietschel
  • Function : Author
Margarita Rivera
  • Function : Author
Mary Roberson
  • Function : Author
Martin Schalling
  • Function : Author
Peter Schofield
  • Function : Author
Thomas Schulze
  • Function : Author
Laura Scott
  • Function : Author
Alessandro Serretti
  • Function : Author
Engilbert Sigurdsson
  • Function : Author
Olav Smeland
  • Function : Author
Eystein Stordal
  • Function : Author
Fabian Streit
  • Function : Author
Jana Strohmaier
  • Function : Author
Thorgeir Thorgeirsson
  • Function : Author
Jens Treutlein
  • Function : Author
Gustavo Turecki
  • Function : Author
Arne Vaaler
  • Function : Author
Eduard Vieta
  • Function : Author
John Vincent
  • Function : Author
Yunpeng Wang
  • Function : Author
Stephanie Witt
  • Function : Author
Peter Zandi
  • Function : Author
Roger A.H. Adan
  • Function : Author
Lars Alfredsson
  • Function : Author
Tetsuya Ando
  • Function : Author
Harald Aschauer
  • Function : Author
Jessica Baker
  • Function : Author
Vladimir Bencko
  • Function : Author
Andrew Bergen
  • Function : Author
Andreas Birgegård
  • Function : Author
Vesna Boraska Perica
  • Function : Author
Harry Brandt
  • Function : Author
Roland Burghardt
  • Function : Author
Laura Carlberg
  • Function : Author
Matteo Cassina
  • Function : Author
Maurizio Clementi
  • Function : Author
Philippe Courtet
  • Function : Author
Steven Crawford
  • Function : Author
Scott Crow
  • Function : Author
James Crowley
  • Function : Author
Unna Danner
  • Function : Author
Oliver S.P. Davis
  • Function : Author
Daniela Degortes
  • Function : Author
Janiece Desocio
  • Function : Author
Danielle Dick
  • Function : Author
Christian Dina
  • Function : Author
Elisa Docampo
  • Function : Author
Karin Egberts
  • Function : Author
Stefan Ehrlich
  • Function : Author
Thomas Espeseth
  • Function : Author
Fernando Fernández-Aranda
  • Function : Author
Manfred Fichter
  • Function : Author
Lenka Foretova
  • Function : Author
Monica Forzan
  • Function : Author
Giovanni Gambaro
  • Function : Author
Ina Giegling
  • Function : Author
Fragiskos Gonidakis
  • Function : Author
Philip Gorwood
  • Function : Author
Monica Gratacos Mayora
  • Function : Author
Yiran Guo
  • Function : Author
Katherine Halmi
  • Function : Author
Konstantinos Hatzikotoulas
  • Function : Author
Johannes Hebebrand
  • Function : Author
Sietske Helder
  • Function : Author
Beate Herpertz-Dahlmann
  • Function : Author
Wolfgang Herzog
  • Function : Author
Anke Hinney
  • Function : Author
Hartmut Imgart
  • Function : Author
Susana Jiménez-Murcia
  • Function : Author
Craig Johnson
  • Function : Author
Jennifer Jordan
  • Function : Author
Antonio Julià
  • Function : Author
Deborah Kaminská
  • Function : Author
Leila Karhunen
  • Function : Author
Andreas Karwautz
  • Function : Author
Martien J.H. Kas
  • Function : Author
Walter Kaye
  • Function : Author
Martin Kennedy
  • Function : Author
Youl-Ri Kim
  • Function : Author
Lars Klareskog
  • Function : Author
Kelly Klump
  • Function : Author
Gun Peggy S. Knudsen
  • Function : Author
Mikael Landén
  • Function : Author
Stephanie Le Hellard
  • Function : Author
Robert Levitan
  • Function : Author
Dong Li
  • Function : Author
Paul Lichtenstein
  • Function : Author
Mario Maj
  • Function : Author
Sara Marsal
  • Function : Author
Sara Mcdevitt
  • Function : Author
James Mitchell
  • Function : Author
Palmiero Monteleone
  • Function : Author
Alessio Maria Monteleone
  • Function : Author
Melissa Munn-Chernoff
  • Function : Author
Benedetta Nacmias
  • Function : Author
Marie Navratilova
  • Function : Author
Julie O’toole
  • Function : Author
Leonid Padyukov
  • Function : Author
Jacques Pantel
  • Function : Author
Hana Papezova
  • Function : Author
Raquel Rabionet
  • Function : Author
Anu Raevuori
  • Function : Author
Nicolas Ramoz
  • Function : Author
Ted Reichborn-Kjennerud
  • Function : Author
Valdo Ricca
  • Function : Author
Marion Roberts
  • Function : Author
Dan Rujescu
  • Function : Author
Filip Rybakowski
  • Function : Author
André Scherag
  • Function : Author
Ulrike Schmidt
  • Function : Author
Jochen Seitz
  • Function : Author
Lenka Slachtova
  • Function : Author
Agnieszka Slopien
  • Function : Author
Sandro Sorbi
  • Function : Author
Lorraine Southam
  • Function : Author
Michael Strober
  • Function : Author
Alfonso Tortorella
  • Function : Author
Federica Tozzi
  • Function : Author
Janet Treasure
  • Function : Author
Konstantinos Tziouvas
  • Function : Author
Annemarie van Elburg
  • Function : Author
Tracey Wade
  • Function : Author
Gudrun Wagner
  • Function : Author
Esther Walton
  • Function : Author
Hunna Watson
  • Function : Author
H-Erich Wichmann
  • Function : Author
D. Blake Woodside
  • Function : Author
Eleftheria Zeggini
  • Function : Author
Stephanie Zerwas
  • Function : Author
Stephan Zipfel
  • Function : Author
Mark Adams
  • Function : Author
Till F.M. Andlauer
  • Function : Author
Klaus Berger
  • Function : Author
Elisabeth Binder
  • Function : Author
Dorret Boomsma
  • Function : Author
Enrique Castelao
  • Function : Author
Lucía Colodro-Conde
  • Function : Author
Nese Direk
  • Function : Author
Anna Docherty
  • Function : Author
Enrico Domenici
  • Function : Author
Katharina Domschke
  • Function : Author
Erin Dunn
  • Function : Author
Jerome Foo
  • Function : Author
E.J.C. De. Geus
  • Function : Author
Hans Grabe
  • Function : Author
Steven Hamilton
  • Function : Author
Carsten Horn
  • Function : Author
Jouke-Jan Hottenga
  • Function : Author
David Howard
  • Function : Author
Marcus Ising
  • Function : Author
Stefan Kloiber
  • Function : Author
Douglas Levinson
  • Function : Author
Glyn Lewis
  • Function : Author
Patrik K.E. Magnusson
  • Function : Author
Hamdi Mbarek
  • Function : Author
Christel Middeldorp
  • Function : Author
Sara Mostafavi
  • Function : Author
Dale Nyholt
  • Function : Author
Brenda Wjh. Penninx
  • Function : Author
Roseann Peterson
  • Function : Author
Giorgio Pistis
  • Function : Author
David Porteous
  • Function : Author
Martin Preisig
  • Function : Author
Jorge Quiroz
  • Function : Author
Catherine Schaefer
  • Function : Author
Eva Schulte
  • Function : Author
Jianxin Shi
  • Function : Author
Daniel Smith
  • Function : Author
Pippa Thomson
  • Function : Author
Henning Tiemeier
  • Function : Author
Rudolf Uher
  • Function : Author
Sandra van der Auwera
  • Function : Author
Myrna Weissman
  • Function : Author
Madeline Alexander
  • Function : Author
Martin Begemann
  • Function : Author
Elvira Bramon
  • Function : Author
Nancy Buccola
  • Function : Author
Murray Cairns
  • Function : Author
Dominique Campion
  • Function : Author
Vaughan Carr
  • Function : Author
C. Robert Cloninger
  • Function : Author
David Cohen
  • Function : Author
David Collier
  • Function : Author
Aiden Corvin
  • Function : Author
Lynn Delisi
  • Function : Author
Gary Donohoe
  • Function : Author
Frank Dudbridge
  • Function : Author
Jubao Duan
  • Function : Author
Robert Freedman
  • Function : Author
Pablo Gejman
  • Function : Author
Vera Golimbet
  • Function : Author
Stephanie Godard
  • Function : Author
Hannelore Ehrenreich
  • Function : Author
Frans Henskens
  • Function : Author
Masashi Ikeda
  • Function : Author
Nakao Iwata
  • Function : Author
Assen Jablensky
  • Function : Author
Inge Joa
  • Function : Author
Erik Jönsson
  • Function : Author
Brian Kelly
  • Function : Author
Jo Knight
  • Function : Author
Bettina Konte
  • Function : Author
Claudine Laurent-Levinson
  • Function : Author
Jimmy Lee
  • Function : Author
Todd Lencz
  • Function : Author
Bernard Lerer
  • Function : Author
Carmel Loughland
  • Function : Author
Anil Malhotra
  • Function : Author
Jacques Mallet
  • Function : Author
Colm McDonald
  • Function : Author
Marina Mitjans
  • Function : Author
Bryan Mowry
  • Function : Author
Kieran Murphy
  • Function : Author
Robin Murray
  • Function : Author
F. Anthony O’neill
  • Function : Author
Sang-Yun Oh
  • Function : Author
Aarno Palotie
  • Function : Author
Christos Pantelis
  • Function : Author
Ann Pulver
  • Function : Author
Tracey Petryshen
  • Function : Author
Digby Quested
  • Function : Author
Brien Riley
  • Function : Author
Alan Sanders
  • Function : Author
Ulrich Schall
  • Function : Author
Sibylle Schwab
  • Function : Author
Rodney Scott
  • Function : Author
Pak Sham
  • Function : Author
Jeremy Silverman
  • Function : Author
Kang Sim
  • Function : Author
Agnes Steixner
  • Function : Author
Paul Tooney
  • Function : Author
Jim van Os
  • Function : Author
Marquis Vawter
  • Function : Author
Dermot Walsh
  • Function : Author
Mark Weiser
  • Function : Author
Dieter Wildenauer
  • Function : Author
Nigel Williams
  • Function : Author
Brandon Wormley
  • Function : Author
Fuquan Zhang
  • Function : Author
Christos Androutsos
  • Function : Author
Paul Arnold
  • Function : Author
Cathy Barr
  • Function : Author
Csaba Barta
  • Function : Author
Katharina Bey
  • Function : Author
O. Joseph Bienvenu
  • Function : Author
Donald Black
  • Function : Author
Lawrence Brown
  • Function : Author
Cathy Budman
  • Function : Author
Danielle Cath
  • Function : Author
Keun-Ah Cheon
  • Function : Author
Valentina Ciullo
  • Function : Author
Barbara Coffey
  • Function : Author
Daniele Cusi
  • Function : Author
Lea Davis
  • Function : Author
Damiaan Denys
  • Function : Author
Andrea Dietrich
  • Function : Author
Valsamma Eapen
  • Function : Author
Peter Falkai
  • Function : Author
Thomas Fernandez
  • Function : Author
Blanca Garcia-Delgar
  • Function : Author
Daniel Geller
  • Function : Author
Donald Gilbert
  • Function : Author
Marco Grados
  • Function : Author
Erica Greenberg
  • Function : Author
Edna Grünblatt
  • Function : Author
Julie Hagstrøm
  • Function : Author
Gregory Hanna
  • Function : Author
Andreas Hartmann
  • Function : Author
Tammy Hedderly
  • Function : Author
Gary Heiman
  • Function : Author
Isobel Heyman
  • Function : Author
Hyun Ju Hong
  • Function : Author
Alden Huang
  • Function : Author
Chaim Huyser
  • Function : Author
Laura Ibanez-Gomez
  • Function : Author
Ekaterina Khramtsova
  • Function : Author
Young Key Kim
  • Function : Author
Young-Shin Kim
  • Function : Author
Robert King
  • Function : Author
Yun-Joo Koh
  • Function : Author
Anastasios Konstantinidis
  • Function : Author
Sodahm Kook
  • Function : Author
Samuel Kuperman
  • Function : Author
Bennett Leventhal
  • Function : Author
Christine Lochner
  • Function : Author
Andrea Ludolph
  • Function : Author
Marcos Madruga-Garrido
  • Function : Author
Irene Malaty
  • Function : Author
Athanasios Maras
  • Function : Author
James Mccracken
  • Function : Author
Inge Meijer
  • Function : Author
Pablo Mir
  • Function : Author
Astrid Morer
  • Function : Author
Kirsten Müller-Vahl
  • Function : Author
Alexander Münchau
  • Function : Author
Tara Murphy
  • Function : Author
Allan Naarden
  • Function : Author
Peter Nagy
  • Function : Author
Gerald Nestadt
  • Function : Author
Paul Nestadt
  • Function : Author
Humberto Nicolini
  • Function : Author
Erika Nurmi
  • Function : Author
Michael Okun
  • Function : Author
Peristera Paschou
  • Function : Author
Fabrizio Piras
  • Function : Author
Federica Piras
  • Function : Author
Christopher Pittenger
  • Function : Author
Kerstin Plessen
  • Function : Author
Margaret Richter
  • Function : Author
Renata Rizzo
  • Function : Author
Mary Robertson
  • Function : Author
Veit Roessner
  • Function : Author
Stephan Ruhrmann
  • Function : Author
Jack Samuels
  • Function : Author
Paul Sandor
  • Function : Author
Monika Schlögelhofer
  • Function : Author
Eun-Young Shin
  • Function : Author
Harvey Singer
  • Function : Author
Dong-Ho Song
  • Function : Author
Jungeun Song
  • Function : Author
Gianfranco Spalletta
  • Function : Author
Dan Stein
  • Function : Author
S Evelyn Stewart
  • Function : Author
Eric Storch
  • Function : Author
Barbara Stranger
  • Function : Author
Manfred Stuhrmann
  • Function : Author
Zsanett Tarnok
  • Function : Author
Jay Tischfield
  • Function : Author
Jennifer Tübing
  • Function : Author
Frank Visscher
  • Function : Author
Nienke Vulink
  • Function : Author
Michael Wagner
  • Function : Author
Susanne Walitza
  • Function : Author
Sina Wanderer
  • Function : Author
Martin Woods
  • Function : Author
Yulia Worbe
  • Function : Author
Gwyneth Zai
  • Function : Author
Samuel Zinner
  • Function : Author
Patrick Sullivan
  • Function : Author
Barbara Franke
  • Function : Author
Mark Daly
  • Function : Author
Cynthia Bulik
  • Function : Author
Cathryn Lewis
  • Function : Author
Andrew McIntosh
  • Function : Author
Michael O’donovan
  • Function : Author
Amanda Zheutlin
  • Function : Author
Ole Andreassen
  • Function : Author
Anders Børglum
  • Function : Author
Gerome Breen
  • Function : Author
Howard Edenberg
  • Function : Author
Ayman Fanous
  • Function : Author
Stephen Faraone
  • Function : Author
Joel Gelernter
  • Function : Author
Carol Mathews
  • Function : Author
Manuel Mattheisen
  • Function : Author
Karen Mitchell
  • Function : Author
Michael Neale
  • Function : Author
John Nurnberger
  • Function : Author
Stephan Ripke
  • Function : Author
Susan Santangelo
  • Function : Author
Jeremiah Scharf
  • Function : Author
Murray Stein
  • Function : Author
Laura Thornton
  • Function : Author
James T.R. Walters
  • Function : Author
Naomi Wray
  • Function : Author
Daniel Geschwind
  • Function : Author
Benjamin Neale
  • Function : Author
Kenneth Kendler
  • Function : Author
Jordan Smoller
  • Function : Author

Abstract

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.

Dates and versions

hal-04573676 , version 1 (13-05-2024)

Identifiers

Cite

Phil Lee, Verneri Anttila, Hyejung Won, Yen-Chen Feng, Jacob Rosenthal, et al.. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 2019, 179 (7), pp.1469-1482.e11. ⟨10.1016/j.cell.2019.11.020⟩. ⟨hal-04573676⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More