Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility - Sorbonne Université Access content directly
Journal Articles Science Year : 2019

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolaos Patsopoulos , Sergio Baranzini , Adam Santaniello (1) , Parisa Shoostari , Chris Cotsapas (2) , Garrett Wong , Ashley Beecham , Tojo James , Joseph Replogle , Ioannis Vlachos (3) , Cristin Mccabe , Tune Pers , Aaron Brandes , Charles White (4) , Brendan Keenan , Maria Cimpean , Phoebe Winn , Ioannis-Pavlos Panteliadis , Allison Robbins , Till Andlauer (5, 6) , Onigiusz Zarzycki , Bénédicte Dubois , An Goris , Helle Bach Søndergaard , Finn Sellebjerg , Per Soelberg Sorensen , Henrik Ullum , Lise Wegner Thørner , Janna Saarela , Isabelle Cournu-Rebeix , Vincent Damotte , Bertrand Fontaine (7) , Lena Guillot-Noel , Mark Lathrop , Sandra Vukusic , Achim Berthele , Viola Pongratz , Dorothea Buck , Christiane Gasperi , Christiane Graetz , Verena Grummel , Bernhard Hemmer , Muni Hoshi , Benjamin Knier , Thomas Korn , Christina Lill , Felix Luessi , Mark Mühlau , Frauke Zipp , Efthimios Dardiotis , Cristina Agliardi , Antonio Amoroso , Nadia Barizzone , Maria Benedetti , Luisa Bernardinelli , Paola Cavalla , Ferdinando Clarelli , Giancarlo Comi , Daniele Cusi , Federica Esposito , Laura Ferrè , Daniela Galimberti , Clara Guaschino , Maurizio Leone , Vittorio Martinelli , Lucia Moiola , Marco Salvetti , Melissa Sorosina , Domizia Vecchio , Andrea Zauli , Silvia Santoro , Nicasio Mancini , Miriam Zuccalà , Julia Mescheriakova , Cornelia van Duijn , Steffan Bos , Elisabeth Celius , Anne Spurkland , Manuel Comabella , Xavier Montalban , Lars Alfredsson , Izaura Bomfim , David Gomez-Cabrero , Jan Hillert , Maja Jagodic , Magdalena Lindén , Fredrik Piehl , Ilijas Jelčić , Roland Martin , Mirela Sospedra , Amie Baker , Maria Ban , Clive Hawkins , Pirro Hysi , Seema Kalra , Fredrik Karpe , Jyoti Khadake , Genevieve Lachance , Paul Molyneux , Matthew Neville , John Thorpe , Elizabeth Bradshaw , Stacy Caillier , Peter Calabresi , Bruce Cree , Anne Cross , Mary Davis , Paul de Bakker , Silvia Delgado , Marieme Dembele , Keith Edwards , Kate Fitzgerald , Irene Frohlich , Pierre-Antoine Gourraud , Jonathan Haines , Hakon Hakonarson , Dorlan Kimbrough , Noriko Isobe , Ioanna Konidari , Ellen Lathi , Michelle Lee , Taibo Li , David An , Andrew Zimmer , Lohith Madireddy , Clara Manrique , Mitja Mitrovic , Marta Olah , Ellis Patrick , Margaret Pericak-Vance , Laura Piccio , Cathy Schaefer , Howard Weiner , Kasper Lage , Alastair Compston , David Hafler , Hanne Harbo , Stephen Hauser , Graeme Stewart , Sandra D’alfonso , Georgios Hadjigeorgiou , Bruce Taylor , Lisa Barcellos , David Booth , Rogier Hintzen , Ingrid Kockum , Filippo Martinelli-Boneschi , Jacob Mccauley , Jorge Oksenberg , Annette Oturai , Stephen Sawcer , Adrian Ivinson , Tomas Olsson , Philip de Jager
Nikolaos Patsopoulos
  • Function : Author
Sergio Baranzini
  • Function : Author
Parisa Shoostari
  • Function : Author
Garrett Wong
  • Function : Author
Ashley Beecham
  • Function : Author
Tojo James
  • Function : Author
Joseph Replogle
  • Function : Author
Cristin Mccabe
  • Function : Author
Tune Pers
  • Function : Author
Aaron Brandes
  • Function : Author
Brendan Keenan
  • Function : Author
Maria Cimpean
  • Function : Author
Phoebe Winn
  • Function : Author
Ioannis-Pavlos Panteliadis
  • Function : Author
Allison Robbins
  • Function : Author
Onigiusz Zarzycki
  • Function : Author
Bénédicte Dubois
  • Function : Author
An Goris
  • Function : Author
Helle Bach Søndergaard
  • Function : Author
Finn Sellebjerg
  • Function : Author
Per Soelberg Sorensen
  • Function : Author
Henrik Ullum
  • Function : Author
Lise Wegner Thørner
  • Function : Author
Janna Saarela
  • Function : Author
Isabelle Cournu-Rebeix
  • Function : Author
Vincent Damotte
  • Function : Author
Lena Guillot-Noel
  • Function : Author
Mark Lathrop
  • Function : Author
Sandra Vukusic
Achim Berthele
  • Function : Author
Viola Pongratz
  • Function : Author
Dorothea Buck
  • Function : Author
Christiane Gasperi
  • Function : Author
Christiane Graetz
  • Function : Author
Verena Grummel
  • Function : Author
Bernhard Hemmer
  • Function : Author
Muni Hoshi
  • Function : Author
Benjamin Knier
  • Function : Author
Thomas Korn
  • Function : Author
Christina Lill
  • Function : Author
Felix Luessi
  • Function : Author
Mark Mühlau
  • Function : Author
Frauke Zipp
  • Function : Author
Efthimios Dardiotis
  • Function : Author
Cristina Agliardi
  • Function : Author
Antonio Amoroso
  • Function : Author
Nadia Barizzone
  • Function : Author
Maria Benedetti
  • Function : Author
Luisa Bernardinelli
  • Function : Author
Paola Cavalla
  • Function : Author
Ferdinando Clarelli
  • Function : Author
Giancarlo Comi
  • Function : Author
Daniele Cusi
  • Function : Author
Federica Esposito
  • Function : Author
Laura Ferrè
  • Function : Author
Daniela Galimberti
  • Function : Author
Clara Guaschino
  • Function : Author
Maurizio Leone
  • Function : Author
Vittorio Martinelli
  • Function : Author
Lucia Moiola
  • Function : Author
Marco Salvetti
  • Function : Author
Melissa Sorosina
  • Function : Author
Domizia Vecchio
  • Function : Author
Andrea Zauli
  • Function : Author
Silvia Santoro
  • Function : Author
Nicasio Mancini
  • Function : Author
Miriam Zuccalà
  • Function : Author
Julia Mescheriakova
  • Function : Author
Cornelia van Duijn
  • Function : Author
Steffan Bos
  • Function : Author
Elisabeth Celius
  • Function : Author
Anne Spurkland
  • Function : Author
Manuel Comabella
  • Function : Author
Xavier Montalban
  • Function : Author
Lars Alfredsson
  • Function : Author
Izaura Bomfim
  • Function : Author
David Gomez-Cabrero
  • Function : Author
Jan Hillert
  • Function : Author
Maja Jagodic
  • Function : Author
Magdalena Lindén
  • Function : Author
Fredrik Piehl
  • Function : Author
Ilijas Jelčić
  • Function : Author
Roland Martin
  • Function : Author
Mirela Sospedra
  • Function : Author
Amie Baker
  • Function : Author
Maria Ban
  • Function : Author
Clive Hawkins
  • Function : Author
Pirro Hysi
  • Function : Author
Seema Kalra
  • Function : Author
Fredrik Karpe
  • Function : Author
Jyoti Khadake
  • Function : Author
Genevieve Lachance
  • Function : Author
Paul Molyneux
  • Function : Author
Matthew Neville
  • Function : Author
John Thorpe
  • Function : Author
Elizabeth Bradshaw
  • Function : Author
Stacy Caillier
  • Function : Author
Peter Calabresi
  • Function : Author
Bruce Cree
  • Function : Author
Anne Cross
  • Function : Author
Mary Davis
  • Function : Author
Paul de Bakker
  • Function : Author
Silvia Delgado
  • Function : Author
Marieme Dembele
  • Function : Author
Keith Edwards
  • Function : Author
Kate Fitzgerald
  • Function : Author
Irene Frohlich
  • Function : Author
Pierre-Antoine Gourraud
  • Function : Author
Jonathan Haines
  • Function : Author
Hakon Hakonarson
  • Function : Author
Dorlan Kimbrough
  • Function : Author
Noriko Isobe
  • Function : Author
Ioanna Konidari
  • Function : Author
Ellen Lathi
  • Function : Author
Michelle Lee
  • Function : Author
Taibo Li
  • Function : Author
David An
  • Function : Author
Andrew Zimmer
  • Function : Author
Lohith Madireddy
  • Function : Author
Clara Manrique
  • Function : Author
Mitja Mitrovic
  • Function : Author
Marta Olah
  • Function : Author
Ellis Patrick
  • Function : Author
Margaret Pericak-Vance
  • Function : Author
Laura Piccio
  • Function : Author
Cathy Schaefer
  • Function : Author
Howard Weiner
  • Function : Author
Kasper Lage
  • Function : Author
Alastair Compston
  • Function : Author
David Hafler
  • Function : Author
Hanne Harbo
  • Function : Author
Stephen Hauser
  • Function : Author
Graeme Stewart
  • Function : Author
Sandra D’alfonso
  • Function : Author
Georgios Hadjigeorgiou
  • Function : Author
Bruce Taylor
  • Function : Author
Lisa Barcellos
  • Function : Author
David Booth
  • Function : Author
Rogier Hintzen
  • Function : Author
Ingrid Kockum
  • Function : Author
Filippo Martinelli-Boneschi
  • Function : Author
Jacob Mccauley
  • Function : Author
Jorge Oksenberg
  • Function : Author
Annette Oturai
  • Function : Author
Stephen Sawcer
  • Function : Author
Adrian Ivinson
  • Function : Author
Tomas Olsson
  • Function : Author
Philip de Jager
  • Function : Author

Abstract

Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International Multiple Sclerosis Genetics Consortium identified more than 200 risk loci in MS (see the Perspective by Briggs). Focusing on the best candidate genes, including a model of the major histocompatibility complex region, the authors identified statistically independent effects at the genome level. Gene expression studies detected that every major immune cell type is enriched for MS susceptibility genes and that MS risk variants are enriched in brain-resident immune cells, especially microglia. Up to 48% of the genetic contribution of MS can be explained through this analysis. Science , this issue p. eaav7188 ; see also p. 1383

Dates and versions

hal-04578827 , version 1 (17-05-2024)

Identifiers

Cite

Nikolaos Patsopoulos, Sergio Baranzini, Adam Santaniello, Parisa Shoostari, Chris Cotsapas, et al.. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 2019, 365 (6460), ⟨10.1126/science.aav7188⟩. ⟨hal-04578827⟩
0 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More