Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolaos Patsopoulos; Sergio Baranzini; Adam Santaniello; Parisa Shoostari; Chris Cotsapas; Garrett Wong; Ashley Beecham; Tojo James; Joseph Replogle; Ioannis Vlachos; Cristin Mccabe; Tune Pers; Aaron Brandes; Charles White; Brendan Keenan; Maria Cimpean; Phoebe Winn; Ioannis-Pavlos Panteliadis; Allison Robbins; Till Andlauer; Onigiusz Zarzycki; Bénédicte Dubois; An Goris; Helle Bach Søndergaard; Finn Sellebjerg; Per Soelberg Sorensen; Henrik Ullum; Lise Wegner Thørner; Janna Saarela; Isabelle Cournu-Rebeix; Vincent Damotte; Bertrand Fontaine; Lena Guillot-Noel; Mark Lathrop; Sandra Vukusic; Achim Berthele; Viola Pongratz; Dorothea Buck; Christiane Gasperi; Christiane Graetz; Verena Grummel; Bernhard Hemmer; Muni Hoshi; Benjamin Knier; Thomas Korn; Christina Lill; Felix Luessi; Mark Mühlau; Frauke Zipp; Efthimios Dardiotis; Cristina Agliardi; Antonio Amoroso; Nadia Barizzone; Maria Benedetti; Luisa Bernardinelli; Paola Cavalla; Ferdinando Clarelli; Giancarlo Comi; Daniele Cusi; Federica Esposito; Laura Ferrè; Daniela Galimberti; Clara Guaschino; Maurizio Leone; Vittorio Martinelli; Lucia Moiola; Marco Salvetti; Melissa Sorosina; Domizia Vecchio; Andrea Zauli; Silvia Santoro; Nicasio Mancini; Miriam Zuccalà; Julia Mescheriakova; Cornelia van Duijn; Steffan Bos; Elisabeth Celius; Anne Spurkland; Manuel Comabella; Xavier Montalban; Lars Alfredsson; Izaura Bomfim; David Gomez-Cabrero; Jan Hillert; Maja Jagodic; Magdalena Lindén; Fredrik Piehl; Ilijas Jelčić; Roland Martin; Mirela Sospedra; Amie Baker; Maria Ban; Clive Hawkins; Pirro Hysi; Seema Kalra; Fredrik Karpe; Jyoti Khadake; Genevieve Lachance; Paul Molyneux; Matthew Neville; John Thorpe; Elizabeth Bradshaw; Stacy Caillier; Peter Calabresi; Bruce Cree; Anne Cross; Mary Davis; Paul de Bakker; Silvia Delgado; Marieme Dembele; Keith Edwards; Kate Fitzgerald; Irene Frohlich; Pierre-Antoine Gourraud; Jonathan Haines; Hakon Hakonarson; Dorlan Kimbrough; Noriko Isobe; Ioanna Konidari; Ellen Lathi; Michelle Lee; Taibo Li; David An; Andrew Zimmer; Lohith Madireddy; Clara Manrique; Mitja Mitrovic; Marta Olah; Ellis Patrick; Margaret Pericak-Vance; Laura Piccio; Cathy Schaefer; Howard Weiner; Kasper Lage; Alastair Compston; David Hafler; Hanne Harbo; Stephen Hauser; Graeme Stewart; Sandra D’alfonso; Georgios Hadjigeorgiou; Bruce Taylor; Lisa Barcellos; David Booth; Rogier Hintzen; Ingrid Kockum; Filippo Martinelli-Boneschi; Jacob Mccauley; Jorge Oksenberg; Annette Oturai; Stephen Sawcer; Adrian Ivinson; Tomas Olsson; Philip de Jager

doi:10.1126/science.aav7188

Journal Articles Science Year : 2019

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

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Nikolaos Patsopoulos

Function : Author

Sergio Baranzini

Function : Author

Adam Santaniello

Function : Author

University of California [San Francisco]

Parisa Shoostari

Function : Author

Chris Cotsapas

Function : Author

Yale School of Medicine [New Haven, Connecticut]

Garrett Wong

Function : Author

Ashley Beecham

Function : Author

Tojo James

Function : Author

Joseph Replogle

Function : Author

Ioannis Vlachos

Function : Author

National and Kapodistrian University of Athens

Cristin Mccabe

Function : Author

Tune Pers

Function : Author

Aaron Brandes

Function : Author

Charles White

Function : Author

Génétique, Reproduction et Développement

Brendan Keenan

Function : Author

Maria Cimpean

Function : Author

Phoebe Winn

Function : Author

Ioannis-Pavlos Panteliadis

Function : Author

Allison Robbins

Function : Author

Till Andlauer

Function : Author

Max Planck Institute of Psychiatry

Technische Universität Munchen - Technical University Munich - Université Technique de Munich

Onigiusz Zarzycki

Function : Author

Bénédicte Dubois

Function : Author

An Goris

Function : Author

Helle Bach Søndergaard

Function : Author

Finn Sellebjerg

Function : Author

Per Soelberg Sorensen

Function : Author

Henrik Ullum

Function : Author

Lise Wegner Thørner

Function : Author

Janna Saarela

Function : Author

Isabelle Cournu-Rebeix

Function : Author

Vincent Damotte

Function : Author

Bertrand Fontaine

Function : Author

Institut du Cerveau = Paris Brain Institute

Lena Guillot-Noel

Function : Author

Mark Lathrop

Function : Author

Sandra Vukusic

Function : Author
PersonId : 962598
ORCID : 0000-0001-7337-7122

Achim Berthele

Function : Author

Viola Pongratz

Function : Author

Dorothea Buck

Function : Author

Christiane Gasperi

Function : Author

Christiane Graetz

Function : Author

Verena Grummel

Function : Author

Bernhard Hemmer

Function : Author

Muni Hoshi

Function : Author

Benjamin Knier

Function : Author

Thomas Korn

Function : Author

Christina Lill

Function : Author

Felix Luessi

Function : Author

Mark Mühlau

Function : Author

Frauke Zipp

Function : Author

Efthimios Dardiotis

Function : Author

Cristina Agliardi

Function : Author

Antonio Amoroso

Function : Author

Nadia Barizzone

Function : Author

Maria Benedetti

Function : Author

Luisa Bernardinelli

Function : Author

Paola Cavalla

Function : Author

Ferdinando Clarelli

Function : Author

Giancarlo Comi

Function : Author

Daniele Cusi

Function : Author

Federica Esposito

Function : Author

Laura Ferrè

Function : Author

Daniela Galimberti

Function : Author

Clara Guaschino

Function : Author

Maurizio Leone

Function : Author

Vittorio Martinelli

Function : Author

Lucia Moiola

Function : Author

Marco Salvetti

Function : Author

Melissa Sorosina

Function : Author

Domizia Vecchio

Function : Author

Andrea Zauli

Function : Author

Silvia Santoro

Function : Author

Nicasio Mancini

Function : Author

Miriam Zuccalà

Function : Author

Julia Mescheriakova

Function : Author

Cornelia van Duijn

Function : Author

Steffan Bos

Function : Author

Elisabeth Celius

Function : Author

Anne Spurkland

Function : Author

Manuel Comabella

Function : Author

Xavier Montalban

Function : Author

Lars Alfredsson

Function : Author

Izaura Bomfim

Function : Author

David Gomez-Cabrero

Function : Author

Jan Hillert

Function : Author

Maja Jagodic

Function : Author

Magdalena Lindén

Function : Author

Fredrik Piehl

Function : Author

Ilijas Jelčić

Function : Author

Roland Martin

Function : Author

Mirela Sospedra

Function : Author

Amie Baker

Function : Author

Maria Ban

Function : Author

Clive Hawkins

Function : Author

Pirro Hysi

Function : Author

Seema Kalra

Function : Author

Fredrik Karpe

Function : Author

Jyoti Khadake

Function : Author

Genevieve Lachance

Function : Author

Paul Molyneux

Function : Author

Matthew Neville

Function : Author

John Thorpe

Function : Author

Elizabeth Bradshaw

Function : Author

Stacy Caillier

Function : Author

Peter Calabresi

Function : Author

Bruce Cree

Function : Author

Anne Cross

Function : Author

Mary Davis

Function : Author

Paul de Bakker

Function : Author

Silvia Delgado

Function : Author

Marieme Dembele

Function : Author

Keith Edwards

Function : Author

Kate Fitzgerald

Function : Author

Irene Frohlich

Function : Author

Pierre-Antoine Gourraud

Function : Author
PersonId : 762977
ORCID : 0000-0003-1131-9554
IdRef : 195137280

Centre de Recherche en Transplantation et Immunologie

Jonathan Haines

Function : Author

Hakon Hakonarson

Function : Author

Dorlan Kimbrough

Function : Author

Noriko Isobe

Function : Author

Ioanna Konidari

Function : Author

Ellen Lathi

Function : Author

Michelle Lee

Function : Author

Taibo Li

Function : Author

David An

Function : Author

Andrew Zimmer

Function : Author

Lohith Madireddy

Function : Author

Clara Manrique

Function : Author

Mitja Mitrovic

Function : Author

Marta Olah

Function : Author

Ellis Patrick

Function : Author

Margaret Pericak-Vance

Function : Author

Laura Piccio

Function : Author

Cathy Schaefer

Function : Author

Howard Weiner

Function : Author

Kasper Lage

Function : Author

Alastair Compston

Function : Author

David Hafler

Function : Author

Hanne Harbo

Function : Author

Stephen Hauser

Function : Author

Graeme Stewart

Function : Author

Sandra D’alfonso

Function : Author

Georgios Hadjigeorgiou

Function : Author

Bruce Taylor

Function : Author

Lisa Barcellos

Function : Author

David Booth

Function : Author

Rogier Hintzen

Function : Author

Ingrid Kockum

Function : Author

Filippo Martinelli-Boneschi

Function : Author

Jacob Mccauley

Function : Author

Jorge Oksenberg

Function : Author

Annette Oturai

Function : Author

Stephen Sawcer

Function : Author

Adrian Ivinson

Function : Author

Tomas Olsson

Function : Author

Philip de Jager

Function : Author

Abstract

Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International Multiple Sclerosis Genetics Consortium identified more than 200 risk loci in MS (see the Perspective by Briggs). Focusing on the best candidate genes, including a model of the major histocompatibility complex region, the authors identified statistically independent effects at the genome level. Gene expression studies detected that every major immune cell type is enriched for MS susceptibility genes and that MS risk variants are enriched in brain-resident immune cells, especially microglia. Up to 48% of the genetic contribution of MS can be explained through this analysis. Science , this issue p. eaav7188 ; see also p. 1383

Domains

Human health and pathology

Gestionnaire HAL 5 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-04578827

Submitted on : Friday, May 17, 2024-11:01:53 AM

Last modification on : Tuesday, November 19, 2024-2:04:09 PM

Dates and versions

hal-04578827 , version 1 (17-05-2024)

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HAL Id : hal-04578827 , version 1
DOI : 10.1126/science.aav7188
PUBMED : 31604244
PUBMEDCENTRAL : PMC7241648

Cite

Nikolaos Patsopoulos, Sergio Baranzini, Adam Santaniello, Parisa Shoostari, Chris Cotsapas, et al.. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 2019, 365 (6460), ⟨10.1126/science.aav7188⟩. ⟨hal-04578827⟩

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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

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