Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors - Sorbonne Université Access content directly
Journal Articles Nature Neuroscience Year : 2021

Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors

Abstract

Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal activity and suppressing prepotent inappropriate actions. To investigate the potential role of striatal PVIs in regulating compulsive behaviors, we assessed excessive self-grooming—a behavioral metric of compulsive-like behavior—in male Sapap3 knockout mice (Sapap3-KO). Continuous optogenetic activation of PVIs in striatal areas receiving input from the lateral orbitofrontal cortex reduced self-grooming events in Sapap3-KO mice to wild-type levels. Aiming to shorten the critical time window for PVI recruitment, we then provided real-time closed-loop optogenetic stimulation of striatal PVIs, using a transient power increase in the 1–4 Hz frequency band in the orbitofrontal cortex as a predictive biomarker of grooming onsets. Targeted closed-loop stimulation at grooming onsets was as effective as continuous stimulation in reducing grooming events but required 87% less stimulation time, paving the way for adaptive stimulation therapeutic protocols.
Fichier principal
Vignette du fichier
Mondragon_Schreiweis_NatNeuro_2024.pdf (4.27 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-04587806 , version 1 (24-05-2024)

Licence

Identifiers

Cite

Sirenia Lizbeth Mondragón-González, Christiane Schreiweis, Eric Burguière. Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors. Nature Neuroscience, 2021, ⟨10.1038/s41593-024-01633-3⟩. ⟨hal-04587806⟩
0 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More