Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study - Sorbonne Université
Journal Articles Neurobiology of Aging Year : 2017

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang
  • Function : Author
M.G. Heckman
  • Function : Author
Jan O Aasly
  • Function : Author
Grazia Annesi
  • Function : Author
Maria Bozi
  • Function : Author
Sun Ju Chung
  • Function : Author
Carl Clarke
  • Function : Author
David Crosiers
  • Function : Author
Gertrud Eckstein
  • Function : Author
Gaetan Garraux
  • Function : Author
Georgios M Hadjigeorgiou
  • Function : Author
Nobu Hattori
  • Function : Author
Beom Jeon
  • Function : Author
Yun J Kim
  • Function : Author
Masato Kubo
  • Function : Author
Juei Jueng Lin
  • Function : Author
Timothy Lynch
  • Function : Author
Peter Lichtner
  • Function : Author
George D Mellick
  • Function : Author
Vincent Mok
  • Function : Author
Karin E Morrison
  • Function : Author
Aldo Quattrone
  • Function : Author
Wataru Satake
  • Function : Author
Peter A Silburn
  • Function : Author
Leonidas Stefanis
  • Function : Author
Joanne D Stockton
  • Function : Author
Eng King Tan
  • Function : Author
Tatsushi Toda
  • Function : Author
Alexis Brice
Christine van Broeckhoven
  • Function : Author
Ryan J Uitti
  • Function : Author
Karin Wirdefeldt
  • Function : Author
Zbigniew Wszolek
  • Function : Author
Georgia Xiromerisiou
  • Function : Author
Demetrius M Maraganore
  • Function : Author
Thomas Gasser
  • Function : Author
Rejko Krüger
  • Function : Author
Matthew J Farrer
  • Function : Author
Owen A Ross
  • Function : Author
Manu Sharma
  • Function : Author
Michael G Heckman
  • Function : Author

Abstract

A recent study has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of PD (MacLeod D. et al, 2013). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multi-center series of PD patients (5769) and controls (4988) from sites participating in the Genetic Epidemiology of Parkinson’s Disease (GEoPD) consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however given the role of retromer and lysosomal pathways in PD, further studies are warranted.
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hal-04590351 , version 1 (28-05-2024)

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Lisa Wang, M.G. Heckman, Jan O Aasly, Grazia Annesi, Maria Bozi, et al.. Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging, 2017, 49, pp.217.e1-217.e4. ⟨10.1016/j.neurobiolaging.2016.09.022⟩. ⟨hal-04590351⟩
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