Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang; M.G. Heckman; Jan O Aasly; Grazia Annesi; Maria Bozi; Sun Ju Chung; Carl Clarke; David Crosiers; Gertrud Eckstein; Gaetan Garraux; Georgios M Hadjigeorgiou; Nobu Hattori; Beom Jeon; Yun J Kim; Masato Kubo; Suzanne Lesage; Juei Jueng Lin; Timothy Lynch; Peter Lichtner; George D Mellick; Vincent Mok; Karin E Morrison; Aldo Quattrone; Wataru Satake; Peter A Silburn; Leonidas Stefanis; Joanne D Stockton; Eng King Tan; Tatsushi Toda; Alexis Brice; Christine van Broeckhoven; Ryan J Uitti; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Demetrius M Maraganore; Thomas Gasser; Rejko Krüger; Matthew J Farrer; Owen A Ross; Manu Sharma; Michael G Heckman

doi:10.1016/j.neurobiolaging.2016.09.022

Journal Articles Neurobiology of Aging Year : 2017

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

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Lisa Wang

Function : Author

M.G. Heckman

Function : Author

Jan O Aasly

Function : Author

Grazia Annesi

Function : Author

Maria Bozi

Function : Author

Sun Ju Chung

Function : Author

Carl Clarke

Function : Author

David Crosiers

Function : Author

Gertrud Eckstein

Function : Author

Gaetan Garraux

Function : Author

Georgios M Hadjigeorgiou

Function : Author

Nobu Hattori

Function : Author

Beom Jeon

Function : Author

Yun J Kim

Function : Author

Masato Kubo

Function : Author

Suzanne Lesage

Function : Author

Institut du Cerveau = Paris Brain Institute

Juei Jueng Lin

Function : Author

Timothy Lynch

Function : Author

Peter Lichtner

Function : Author

George D Mellick

Function : Author

Vincent Mok

Function : Author

Karin E Morrison

Function : Author

Aldo Quattrone

Function : Author

Wataru Satake

Function : Author

Peter A Silburn

Function : Author

Leonidas Stefanis

Function : Author

Joanne D Stockton

Function : Author

Eng King Tan

Function : Author

Tatsushi Toda

Function : Author

Alexis Brice

Function : Author
PersonId : 1104774
ORCID : 0000-0002-0941-3990
IdRef : 050512935

Christine van Broeckhoven

Function : Author

Ryan J Uitti

Function : Author

Karin Wirdefeldt

Function : Author

Zbigniew Wszolek

Function : Author

Georgia Xiromerisiou

Function : Author

Demetrius M Maraganore

Function : Author

Thomas Gasser

Function : Author

Rejko Krüger

Function : Author

Matthew J Farrer

Function : Author

Owen A Ross

Function : Author

Manu Sharma

Function : Author

Michael G Heckman

Function : Author

Abstract

A recent study has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of PD (MacLeod D. et al, 2013). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multi-center series of PD patients (5769) and controls (4988) from sites participating in the Genetic Epidemiology of Parkinson’s Disease (GEoPD) consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however given the role of retromer and lysosomal pathways in PD, further studies are warranted.

Keywords

Genetic epidemiology LRRK2 PARK16 Parkinson's disease

Domains

Human health and pathology

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https://hal.sorbonne-universite.fr/hal-04590351

Submitted on : Tuesday, May 28, 2024-11:33:10 AM

Last modification on : Wednesday, October 30, 2024-6:16:25 PM

Long-term archiving on : Thursday, August 29, 2024-6:30:45 PM

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hal-04590351 , version 1 (28-05-2024)

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HAL Id : hal-04590351 , version 1
DOI : 10.1016/j.neurobiolaging.2016.09.022
PUBMED : 27814993
PUBMEDCENTRAL : PMC5154911

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Lisa Wang, M.G. Heckman, Jan O Aasly, Grazia Annesi, Maria Bozi, et al.. Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging, 2017, 49, pp.217.e1-217.e4. ⟨10.1016/j.neurobiolaging.2016.09.022⟩. ⟨hal-04590351⟩

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Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

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