In the present work, a reduced graphene oxide (rGO) modified-Fe 3 O 4 doped bifunctional carbon felt cathode (rGO-Fe 3 O 4 /CF) that is capable of generating and converting H 2 O 2 into hydroxyl radicals ( • OH) on-site was fabricated, thus removing the need for an external catalyst. In addition, an rGO-modified cathode (rGO/CF) with high H 2 O 2 production efficiency and a heterogeneous Fenton catalyst (CNT-Fe 3 O 4 ) with magnetic properties were fabricated. The study examined the degradation and mineralization of the cytostatic drug cytarabine (CYT) using two HEF configurations: (i) a bifunctional cathode rGO-Fe 3 O 4 /CF and (ii) a combination of the rGO/CF cathode with CNT-Fe 3 O 4 catalyst. The effects of parameters such as catalyst concentration, initial pH, and applied current were studied. HPLC and ion chromatography analyses were used to identify carboxylic acids and inorganic end-products, respectively. The results show that 0.1 mM CYT was completely degraded within 18 min at an applied current of 300 mA in the HEF system with the rGO-Fe 3 O 4 /CF bifunctional cathode. Total organic carbon (TOC) analysis revealed that the bifunctional cathode system achieved 98.2% mineralization of CYT after 4 h of treatment at 300 mA. Using the rGO/CF cathode and CNT-Fe 3 O 4 catalyst cell, total degradation of 0.1 mM.