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Le facteur d'élongation de la traduction eEF1B : structure macromoléculaire et relation avec le cycle cellulaire

Abstract : Protein synthesis is critical step during the regulation of gene expression. it implies the coordination of divers factors during three steps called initiation, elongation and release, thus allowing the production of proteins at the right place and at the rigth time. the elongation factor eEF1 is made-up of two entities: a G protein called eEF1A and a GDP/GTP exange complex called eEF1B which canonical role is to reactivate eEF1A. Our results concern particularly the eEF1 complex structure, and we show the co-expression of different subsets of the complex within the cell. Moreover, our results demonstrate a cell cycle-derected relocalisation of the eEF1B complex subsets. Finally, sequences analysis lead us to hypothesise that the eEF1B complex is a universal CDK1/Cyclin B target. Altogether, our results show the importance of regulation of the eEF1B complex and globally elongation, associated with the cell cycle.
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https://hal.sorbonne-universite.fr/tel-01117560
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Submitted on : Tuesday, February 17, 2015 - 2:42:55 PM
Last modification on : Thursday, March 12, 2020 - 4:56:01 PM
Document(s) archivé(s) le : Monday, May 18, 2015 - 10:30:20 AM

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  • HAL Id : tel-01117560, version 1

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Frédéric Le Sourd. Le facteur d'élongation de la traduction eEF1B : structure macromoléculaire et relation avec le cycle cellulaire. Biologie cellulaire. Rennes 1, 2006. Français. ⟨tel-01117560⟩

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