The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial - Sorbonne Université
Journal Articles Drug Design, Development and Therapy Year : 2015

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial

Abstract

Background: Paracetamol’s (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans. Methods and results: This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli with APAP or placebo administration. Region-of-interest analysis revealed that activity in response to noxious stimulation diminished with APAP compared to placebo in prefrontal cortices, insula, thalami, anterior cingulate cortex, and periaqueductal gray matter. Conclusion: These findings suggest an inhibitory effect of APAP on spinothalamic tracts leading to a decreased activation of higher structures, and a top-down influence on descending inhibition. Further binding and connectivity studies are needed to evaluate how APAP modulates pain, especially in the context of repeated administration to patients with pain.
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hal-01214449 , version 1 (12-10-2015)

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Gisèle Pickering, Adrian Kastler, Nicolas Macian, Bruno Pereira, Romain Valabregue, et al.. The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial. Drug Design, Development and Therapy, 2015, 9, pp.3853-3862. ⟨10.2147/DDDT.S81004⟩. ⟨hal-01214449⟩
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