Miming the cancer-immune system competition by kinetic Monte Carlo simulations - Sorbonne Université
Article Dans Une Revue The Journal of Chemical Physics Année : 2016

Miming the cancer-immune system competition by kinetic Monte Carlo simulations

Résumé

In order to mimic the interactions between cancer and the immune system at cell scale, we propose a minimal model of cell interactions that is similar to a chemical mechanism including autocatalytic steps. The cells are supposed to bear a quantity called activity that may increase during the interactions. The fluctuations of cell activity are controlled by a so-called thermostat. We develop a kinetic Monte Carlo algorithm to simulate the cell interactions and thermalization of cell activity. The model is able to reproduce the well-known behavior of tumors treated by immunotherapy: the first apparent elimination of the tumor by the immune system is followed by a long equilibrium period and the final escape of cancer from immunosurveillance.
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Dates et versions

hal-01386750 , version 1 (24-10-2016)

Identifiants

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Carlo Bianca, Annie Lemarchand. Miming the cancer-immune system competition by kinetic Monte Carlo simulations. The Journal of Chemical Physics, 2016, 145 (15), pp.154108. ⟨10.1063/1.4964778⟩. ⟨hal-01386750⟩
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