Miming the cancer-immune system competition by kinetic Monte Carlo simulations
Résumé
In order to mimic the interactions between cancer and the immune system at cell scale, we propose a minimal model of cell interactions that is similar to a chemical mechanism including autocatalytic steps. The cells are supposed to bear a quantity called activity that may increase during the interactions. The fluctuations of cell activity are controlled by a so-called thermostat. We develop a kinetic Monte Carlo algorithm to simulate the cell interactions and thermalization of cell activity. The model is able to reproduce the well-known behavior of tumors treated by immunotherapy: the first apparent elimination of the tumor by the immune system is followed by a long equilibrium period and the final escape of cancer from immunosurveillance.
Fichier principal
Bianca_2016_Miming_the.pdf (1.05 Mo)
Télécharger le fichier
lemarchandrev.pdf (579.18 Ko)
Télécharger le fichier
Origine | Fichiers éditeurs autorisés sur une archive ouverte |
---|
Origine | Fichiers produits par l'(les) auteur(s) |
---|
Loading...