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Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2017

Two-level diagnostic classification using cerebrospinal fluid YKL-40 in Alzheimer's disease

Foudil Lamari

Résumé

Introduction: We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) YKL-40 in discriminating (1) clinical Alzheimer's disease (AD) from cognitively healthy controls (HCs) and frontotemporal dementia (FTD) (level I) and (2) patients stratified by different pathophysiological profiles from HCs and FTD following a novel unbiased/descriptive categorization based on CSF biomarkers, independent of cognitive impairment severity (level II). Methods:YKL-40 was compared among HCs (n = 21), mild cognitive impairment (n = 41), AD (n = 35), and FTD (n = 9) (level I) and among HCs (n = 21), AD pathophysiology (tau and amyloid-β) negative (n = 15), tau positive (n = 15), amyloid-β positive (n = 13), AD pathophysiology positive (n = 33), and FTD (n = 9) (level II). Results:Level I: YKL-40 discriminated AD from HC and FTD (area under the receiver operating characteristic curves [AUROCs] = 0.69, 0.71). Level II: YKL-40 discriminated tau-positive individuals and AD pathophysiology–positive individuals from HC, AD pathophysiology–positive patients from FTD (AUROCs = 0.76, 0.72, 0.73). Discussion:YKL-40 demonstrates fair performance in distinguishing tau-positive patients from HCs, suggesting it may aid clinical diagnosis and support a biomarker-guided pathophysiological stratification.
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Dates et versions

hal-01496140 , version 1 (27-03-2017)

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Filippo Baldacci, Nicola Toschi, Simone Lista, Henrik Zetterberg, Kaj Blennow, et al.. Two-level diagnostic classification using cerebrospinal fluid YKL-40 in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, ⟨10.1016/j.jalz.2017.01.021⟩. ⟨hal-01496140⟩
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