Cerebrovascular events are associated with lower survival in giant cell arteritis: a case-controlled multicenter study

Abstract : Giant-cell arteritis (GCA) is a large-vessel vasculitis usually affecting individuals over 50 years old; half of cases are associated with polymyalgia rheumatica [1]. The aorta and its large arterial branches are typically involved, particularly the branches of the external carotids, leading to headache, jaw claudication, scalp tenderness and temporal artery thickening [2]. GCA affects the aorta and its large branches in up to 83% of cases, leading to aneurysms or arterial stenosis [3].Internal carotids and vertebral arteries are less commonly involved and may be responsible for ischemic cerebrovascular events in cases of stenosis or occlusion. Strokes in GCA patients occur frequently in the first year after diagnosis and may sometimes be the initial symptom of GCA. The impact of stroke on mortality in GCA patients has not been well evaluated.
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Thibaud Chazal, Priscille Couture, Charlotte Rosso, Julien Haroche, Anne Léger, et al.. Cerebrovascular events are associated with lower survival in giant cell arteritis: a case-controlled multicenter study. Joint Bone Spine, Elsevier Masson, 2017, 〈10.1016/j.jbspin.2017.05.017〉. 〈hal-01537866〉

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