Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis - Sorbonne Université Access content directly
Journal Articles Marine drugs Year : 2018

Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

Abstract

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC 50 values of 0.7 µM and 1.3 µM, respectively.
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hal-01834017 , version 1 (10-07-2018)

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Amr El-Demerdash, Céline Moriou, Jordan Toullec, Marc Besson, Stéphanie Soulet, et al.. Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis. Marine drugs, 2018, 16 (5), pp.146. ⟨10.3390/md16050146⟩. ⟨hal-01834017⟩
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