Preparation of unsymmetrically 2A,3B,6C(F)-trihydroxy-per-O-methylated α-cyclodextrin and NMR analysis
Résumé
An straightforward approach wherein an excess of diisobutylaluminum hydride (DIBAL-H, 25.0 equiv), used as a molecular scalpel, is able to strip off three methyl groups from both primary and second faces of pemethylated α-cyclodextrin 1 to provide an unsymmetric 2A,3B,6C(F)-trihydroxy-per-O-methylated α-CD 6 in one step in 35% yield is first described.
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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