Association between lung function decline and obstructive sleep apnoea: the ALEC study - Sorbonne Université Access content directly
Journal Articles Sleep and Breathing Year : 2020

Association between lung function decline and obstructive sleep apnoea: the ALEC study

Fredrik Sundbom
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Mirjam Ljunggren
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Karl A Franklin
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Eva Lindberg
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Christer Janson
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Abstract

Purpose: To study changes in lung function among individuals with a risk of obstructive sleep apnoea (OSA), and if asthma affected this relationship. Methods: We used data from the European Community Respiratory Health Survey II and III, a multicentre general population study. Participants answered questionnaires and performed spirometry at baseline and 10-year follow-up (n = 4,329 attended both visits). Subjects with high risk for OSA were identified from the multivariable apnoea prediction (MAP) index, calculated from BMI, age, gender, and OSA symptoms at follow-up. Asthma was defined as having doctor's diagnosed asthma at follow-up. Primary outcomes were changes in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from baseline to follow-up. Results: Among 5108 participants at follow-up, 991 (19%) had a high risk of OSA based on the MAP index. Participants with high OSA risk more often had wheeze, cough, chest tightness, and breathlessness at follow-up than those with low OSA risk. Lung function declined more rapidly in subjects with high OSA risk (low vs high OSA risk [mean ± SD]: FEV1 = - 41.3 ± 24.3 ml/year vs - 50.8 ± 30.1 ml/year; FVC = - 30.5 ± 31.2 ml/year vs - 45.2 ± 36.3 ml/year). Lung function decline was primarily associated with higher BMI and OSA symptoms. OSA symptoms had a stronger association with lung function decline among asthmatics, compared to non-asthmatics. Conclusion: In the general population, a high probability of obstructive sleep apnoea was related to faster lung function decline in the previous decade. This was driven by a higher BMI and more OSA symptoms among these subjects. The association between OSA symptoms and lung function decline was stronger among asthmatics.
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Dates and versions

hal-02934285 , version 1 (09-09-2020)

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Össur Ingi Emilsson, Fredrik Sundbom, Mirjam Ljunggren, Bryndis Benediktsdottir, Judith Garcia-Aymerich, et al.. Association between lung function decline and obstructive sleep apnoea: the ALEC study. Sleep and Breathing, inPress, ⟨10.1007/s11325-020-02086-1⟩. ⟨hal-02934285⟩
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