A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics - Sorbonne Université Access content directly
Journal Articles Nephron Physiology Year : 2022

A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics

Abstract

Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown. Objectives: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics. Methods: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed. Results: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics. Conclusion: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.
Fichier principal
Vignette du fichier
Nephron 2022.pdf (723.41 Ko) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

hal-03922943 , version 1 (25-02-2023)

Licence

Identifiers

Cite

Anxiang Cai, Sandrine Placier, Liliane Louedec, Perrine Frère, Souhila Ouchelouche, et al.. A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics. Nephron Physiology, 2022, pp.1-7. ⟨10.1159/000528259⟩. ⟨hal-03922943⟩
30 View
23 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More