Perspective: plasticity, the enemy of the good - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Cancer Drug Resistance Année : 2019

Perspective: plasticity, the enemy of the good

Résumé

Plasticity is an important feature of modern cancer research. However, the level at which we should consider it remains an open question. Such debate is not new in the field of cancer and can be exemplified by the different models explaining carcinogenesis. Those models mostly explain cell transformation through the deregulation of the internal circuitry. In the last years, those models dramatically increased our knowledge and led to a series of short-term successes in terms of therapeutics. However, cancer drug resistance inevitably arises. Recently, studies on the so-called tumor microenvironment enriched the cell-centered perspective but it also enlarged the complexity of cancer etiology in particular for advanced diseases. Here, we suggest that the plastic and multi-sites specific nature of cancer combined with our incapacity to promise cure should push towards a new perspective where early clinical actions, instead of late ones, should be heralded as the priority of cancer research and care.
Fichier principal
Vignette du fichier
Cancer Drug Resist.pdf (555.68 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03962164 , version 1 (30-01-2023)

Identifiants

Citer

Sarah Yvonnet, Anouk Barberousse, Alexandre E Escargueil. Perspective: plasticity, the enemy of the good. Cancer Drug Resistance, 2019, ⟨10.20517/cdr.2019.23⟩. ⟨hal-03962164⟩
10 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More