ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy
Résumé
Background: Pathophysiology of acute encephalopathy in cirrhotic patients is not completely understood. Factors implicated include ammonia, inflammation, various metabolic disorders and drug toxicity. Recent studies have evidenced an increased permeability of the blood-brain barrier (BBB) in models of chronic liver disease and encephalopathy, either to solutes, or to leukocytes. A modification of the expression of BBB ATP-Binding Cassette (ABC) transporters, actively transporting endogenous and exogenous components through the BBB, has been
Mots clés
BBB
Blood-brain barrier ABC
ATP-binding cassette BDL
Bile duct ligation HE
Hepatic encephalopathy EC
Endothelial cells JAMs
Junctional adhesion molecules CSF
Cerebrospinal fluid
Blood-brain barrier
ABC
ATP-binding cassette
BDL
Bile duct ligation
HE
Hepatic encephalopathy
EC
Endothelial cells
JAMs
Junctional adhesion molecules
CSF