ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy - Sorbonne Université Access content directly
Journal Articles Clinics and Research in Hepatology and Gastroenterology Year : 2022

ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy

Charlotte Bouzbib
  • Function : Author
Haquima El Mourabit
  • Function : Author
Elisabeth Lasnier
  • Function : Author
Sarah Mouri
  • Function : Author
Chantal Housset
Dominique Thabut
  • Function : Author
  • PersonId : 1081430
Nicolas Weiss
Marika Rudler
  • Function : Author

Abstract

Background: Pathophysiology of acute encephalopathy in cirrhotic patients is not completely understood. Factors implicated include ammonia, inflammation, various metabolic disorders and drug toxicity. Recent studies have evidenced an increased permeability of the blood-brain barrier (BBB) in models of chronic liver disease and encephalopathy, either to solutes, or to leukocytes. A modification of the expression of BBB ATP-Binding Cassette (ABC) transporters, actively transporting endogenous and exogenous components through the BBB, has been

Dates and versions

hal-03972206 , version 1 (15-03-2023)

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Charlotte Bouzbib, Haquima El Mourabit, Dominique Wendum, Elisabeth Lasnier, Sarah Mouri, et al.. ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy. Clinics and Research in Hepatology and Gastroenterology, 2022, 46 (9), pp.101784. ⟨10.1016/j.clinre.2021.101784⟩. ⟨hal-03972206⟩
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