RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Anne T Schneider; Jérémie Gautheron; Maria Feoktistova; Christoph Roderburg; Sven H Loosen; Sanchari Roy; Fabian Benz; Peter Schemmer; Markus W Büchler; Ueli Nachbur; Ulf P Neumann; Rene Tolba; Mark Luedde; Jessica Zucman-Rossi; Diana Panayotova-Dimitrova; Martin Leverkus; Christian Preisinger; Frank Tacke; Christian Trautwein; Thomas Longerich; Mihael Vucur; Tom Luedde

doi:10.1016/j.ccell.2016.11.009

Journal Articles Cancer Cell Year : 2017

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

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Anne T Schneider

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Jérémie Gautheron

Function : Author
PersonId : 1222779
IdHAL : jeremiegautheron
ORCID : 0000-0002-7727-9893
IdRef : 163894566

Sorbonne Université

Centre de Recherche Saint-Antoine

Maria Feoktistova

Function : Author

Christoph Roderburg

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Sven H Loosen

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Sanchari Roy

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Fabian Benz

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Peter Schemmer

Function : Author

Heidelberg University Hospital [Heidelberg]

Markus W Büchler

Function : Author

Department for General, Visceral and Transplantation Surgery [Heidelberg, Germany]

Ueli Nachbur

Function : Author

Ulf P Neumann

Function : Author

Rene Tolba

Function : Author

Mark Luedde

Function : Author
PersonId : 1224357

Jessica Zucman-Rossi

Function : Author

Labex Immuno-oncology

Diana Panayotova-Dimitrova

Function : Author

Martin Leverkus

Function : Author

Christian Preisinger

Function : Author

Frank Tacke

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Christian Trautwein

Function : Author

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Thomas Longerich

Function : Author

University of Tübingen

Heidelberg University Hospital [Heidelberg]

Mihael Vucur

Function : Author
PersonId : 1224358

Department of Gene and Cell Medicine and the Immunology Institute

Medical Department III

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Tom Luedde

Function : Author

Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]

Abstract

Highlights d RIPK1 ablation induces TNF-mediated hepatocyte apoptosis without affecting NF-kB d Loss of RIPK1 leads to proteasomal TRAF2 degradation in a kinase-independent manner d RIPK1 and TRAF2 act together to prevent spontaneous HCC development d Low expression of TRAF2 and RIPK1 in human HCC predicts poor prognosis

Keywords

RIP1 RIP3 RIPK3 cIAP-1 Caspase-8 NF-kappaB necroptosis apoptosis HCC hepatocarcinogenesis RIP1 RIP3 RIPK3 cIAP-1 Caspase-8 NF-kappaB necroptosis apoptosis HCC hepatocarcinogenesis

Domains

Life Sciences [q-bio]

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CANCER-CELL-D-16-00040_R4.pdf (10.24 Mo)

Origin : Files produced by the author(s)

Jérémie Gautheron : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-03976528

Submitted on : Tuesday, February 21, 2023-10:26:26 AM

Last modification on : Saturday, October 7, 2023-9:36:21 PM

Long-term archiving on: Monday, May 22, 2023-6:06:11 PM

Dates and versions

hal-03976528 , version 1 (21-02-2023)

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HAL Id : hal-03976528 , version 1
DOI : 10.1016/j.ccell.2016.11.009

Cite

Anne T Schneider, Jérémie Gautheron, Maria Feoktistova, Christoph Roderburg, Sven H Loosen, et al.. RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell, 2017, 31 (1), pp.94-109. ⟨10.1016/j.ccell.2016.11.009⟩. ⟨hal-03976528⟩

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RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

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