RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer - Sorbonne Université Access content directly
Journal Articles Cancer Cell Year : 2017

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Maria Feoktistova
  • Function : Author
Ueli Nachbur
  • Function : Author
Ulf P Neumann
  • Function : Author
Rene Tolba
  • Function : Author
Mark Luedde
  • Function : Author
  • PersonId : 1224357
Diana Panayotova-Dimitrova
  • Function : Author
Martin Leverkus
  • Function : Author
Christian Preisinger
  • Function : Author

Abstract

Highlights d RIPK1 ablation induces TNF-mediated hepatocyte apoptosis without affecting NF-kB d Loss of RIPK1 leads to proteasomal TRAF2 degradation in a kinase-independent manner d RIPK1 and TRAF2 act together to prevent spontaneous HCC development d Low expression of TRAF2 and RIPK1 in human HCC predicts poor prognosis
Fichier principal
Vignette du fichier
CANCER-CELL-D-16-00040_R4.pdf (10.24 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03976528 , version 1 (21-02-2023)

Identifiers

Cite

Anne T Schneider, Jérémie Gautheron, Maria Feoktistova, Christoph Roderburg, Sven H Loosen, et al.. RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell, 2017, 31 (1), pp.94-109. ⟨10.1016/j.ccell.2016.11.009⟩. ⟨hal-03976528⟩
18 View
10 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More