A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy - Sorbonne Université
Article Dans Une Revue (Article De Synthèse) Clinics and Research in Hepatology and Gastroenterology Année : 2021

A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy

Haquima El Mourabit
  • Fonction : Auteur
Pierre-Olivier Couraud
Chantal Housset

Résumé

Background: Hepatic encephalopathy (HE) is a frequent neurological complication of cirrhosis. Evidence suggests a synergic pathophysiological implication of hyperammonemia and systemic inflammation. In addition, the blood-brain barrier (BBB) permeability can be impaired in cirrhotic patients, notably in those displaying HE. We hypothesized that systemic inflammation could trigger leukocytes transendothelial migration (TEM) through the BBB in cirrhotic patients and especially those with HE.
Fichier principal
Vignette du fichier
S2210740121001807.pdf (835.2 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03981504 , version 1 (05-01-2024)

Licence

Identifiants

Citer

Augustin Schaefer, Martin Journaux, Haquima El Mourabit, Sarah Mouri, Dominique Wendum, et al.. A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy. Clinics and Research in Hepatology and Gastroenterology, 2021, 46, ⟨10.1016/j.clinre.2021.101801⟩. ⟨hal-03981504⟩
42 Consultations
9 Téléchargements

Altmetric

Partager

More