A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy - Sorbonne Université Access content directly
Journal Articles (Review Article) Clinics and Research in Hepatology and Gastroenterology Year : 2021

A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy

Haquima El Mourabit
  • Function : Author
Chantal Housset

Abstract

Background: Hepatic encephalopathy (HE) is a frequent neurological complication of cirrhosis. Evidence suggests a synergic pathophysiological implication of hyperammonemia and systemic inflammation. In addition, the blood-brain barrier (BBB) permeability can be impaired in cirrhotic patients, notably in those displaying HE. We hypothesized that systemic inflammation could trigger leukocytes transendothelial migration (TEM) through the BBB in cirrhotic patients and especially those with HE.
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Dates and versions

hal-03981504 , version 1 (05-01-2024)

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Attribution - NonCommercial

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Augustin Schaefer, Martin Journaux, Haquima El Mourabit, Sarah Mouri, Dominique Wendum, et al.. A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy. Clinics and Research in Hepatology and Gastroenterology, 2021, 46, ⟨10.1016/j.clinre.2021.101801⟩. ⟨hal-03981504⟩
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