Article Dans Une Revue Cancers Année : 2023

Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications

Larissa Kotelevets
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Centre de Recherche Saint-Antoine
Eric Chastre
Centre de Recherche Saint-Antoine
Biologie et thérapeutiques du cancer [CRSA]

Résumé

Colorectal cancer (CRC) is a leading public health concern due to its incidence and high mortality rates, highlighting the requirement of an early diagnosis. Evaluation of circulating extracellular vesicles (EVs) might constitute a noninvasive and reliable approach for CRC detection and for patient follow-up because EVs display the molecular features of the cells they originate. EVs are released by almost all cell types and are mainly categorized as exosomes originating from exocytosis of intraluminal vesicles from multivesicular bodies, ectosomes resulting from outward budding of the plasma membrane and apoptotic bodies’ ensuing cell shrinkage. These vesicles play a critical role in intercellular communications during physiological and pathological processes. They facilitate CRC progression and premetastatic niche formation, and they enable transfer of chemotherapy resistance to sensitive cells through the local or remote delivery of their lipid, nucleic acid and protein content. On another note, their stability in the bloodstream, their permeation in tissues and their sheltering of packaged material make engineered EVs suitable vectors for efficient delivery of tracers and therapeutic agents for tumor imaging or treatment. Here, we focus on the physiopathological role of EVs in CRCs, their value in the diagnosis and prognosis and ongoing investigations into therapeutic approaches.

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Sciences du Vivant [q-bio]
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https://hal.sorbonne-universite.fr/hal-04021728

Soumis le : jeudi 9 mars 2023-15:57:21

Dernière modification le : jeudi 14 décembre 2023-13:50:38

Archivage à long terme le : samedi 10 juin 2023-19:54:08

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hal-04021728 , version 1 (09-03-2023)

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Larissa Kotelevets, Eric Chastre. Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications. Cancers, 2023, 15 (4), pp.1107. ⟨10.3390/cancers15041107⟩. ⟨hal-04021728⟩

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