COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective
Jérémie Joffre
(1, 2, 3)
,
Lauren Rodriguez
,
Zachary A Matthay
,
Elliot Lloyd
,
Alexander T Fields
,
Roland J Bainton
,
Philip Kurien
,
Anita Sil
,
Carolyn S Calfee
,
Prescott G Woodruff
,
David J Erle
,
Carolyn Hendrickson
,
Matthew F Krummel
,
Charles R Langelier
,
Michael A Matthay
,
Lucy Z Kornblith
,
Judith Hellman
,
Sharvari Bhide
,
Carolyn S Calfee
,
Sidney A Carrillo
,
Suzanna Chak
,
David J Erle
,
Gabriela K Fragiadakis
,
Rajani Ghale
,
Jeremy Giberson
,
Pat Glenn
,
Ana Gonzalez
,
Carolyn Hendrickson
,
Alejandra Jauregui
,
Norman Jones
,
Kirsten Kangelaris
,
Serena Ke
,
Matthew F Krummel
,
Charles R Langelier
,
Tasha Lea
,
Deanna Lee
,
Aleskandra Lelidowicz
,
Raphael Lota
,
Michael A Matthay
,
Jeff Milush
,
Viet Nguyen
,
Ahmad Sadeed Rashid
,
Nicklaus Rodriguez
,
Austin Sigman
,
Kevin Tang
,
Luz Torres Altamirano
,
Alyssa Ward
,
Andrew Willmore
,
Michael Wilson
,
Prescott G Woodruff
,
Biniam Ambachew
,
Sarah Cary
,
Lauren Chalwell
,
Christopher Colwell
,
Chayse Jones
,
Clayton Josephy
,
Carolyn Hendrickson
,
Deanna Lee
,
Matthieu Legrand
,
Juan Carlos Montoy
,
Aaron E Kornblith
,
Philip Kurien
,
Brenda Nunez-Garcia
,
Viet Nguyen
,
John J Park
,
Arun Prakash
,
Brittany Robinson
,
India Shelley
,
Katherine D Wick
Lauren Rodriguez
- Function : Author
Zachary A Matthay
- Function : Author
Elliot Lloyd
- Function : Author
Alexander T Fields
- Function : Author
Roland J Bainton
- Function : Author
Philip Kurien
- Function : Author
Anita Sil
- Function : Author
Carolyn S Calfee
- Function : Author
Prescott G Woodruff
- Function : Author
David J Erle
- Function : Author
- PersonId : 812903
- ORCID : 0000-0002-2171-0648
Carolyn Hendrickson
- Function : Author
Matthew F Krummel
- Function : Author
Charles R Langelier
- Function : Author
Michael A Matthay
- Function : Author
Lucy Z Kornblith
- Function : Author
- PersonId : 1235682
- ORCID : 0000-0002-1861-9691
Judith Hellman
- Function : Author
- PersonId : 1235681
- ORCID : 0000-0003-2278-6625
Sharvari Bhide
- Function : Author
Carolyn S Calfee
- Function : Author
Sidney A Carrillo
- Function : Author
Suzanna Chak
- Function : Author
David J Erle
- Function : Author
Gabriela K Fragiadakis
- Function : Author
Rajani Ghale
- Function : Author
Jeremy Giberson
- Function : Author
Pat Glenn
- Function : Author
Ana Gonzalez
- Function : Author
Carolyn Hendrickson
- Function : Author
Alejandra Jauregui
- Function : Author
Norman Jones
- Function : Author
Kirsten Kangelaris
- Function : Author
Serena Ke
- Function : Author
Matthew F Krummel
- Function : Author
Charles R Langelier
- Function : Author
Tasha Lea
- Function : Author
Deanna Lee
- Function : Author
Aleskandra Lelidowicz
- Function : Author
Raphael Lota
- Function : Author
Michael A Matthay
- Function : Author
Jeff Milush
- Function : Author
Viet Nguyen
- Function : Author
Ahmad Sadeed Rashid
- Function : Author
Nicklaus Rodriguez
- Function : Author
Austin Sigman
- Function : Author
Kevin Tang
- Function : Author
Luz Torres Altamirano
- Function : Author
Alyssa Ward
- Function : Author
Andrew Willmore
- Function : Author
Michael Wilson
- Function : Author
Prescott G Woodruff
- Function : Author
Biniam Ambachew
- Function : Author
Sarah Cary
- Function : Author
Lauren Chalwell
- Function : Author
Christopher Colwell
- Function : Author
Chayse Jones
- Function : Author
Clayton Josephy
- Function : Author
Carolyn Hendrickson
- Function : Author
Deanna Lee
- Function : Author
Matthieu Legrand
- Function : Author
Juan Carlos Montoy
- Function : Author
Aaron E Kornblith
- Function : Author
Philip Kurien
- Function : Author
Brenda Nunez-Garcia
- Function : Author
Viet Nguyen
- Function : Author
John J Park
- Function : Author
Arun Prakash
- Function : Author
Brittany Robinson
- Function : Author
India Shelley
- Function : Author
Katherine D Wick
- Function : Author
Abstract
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defined. We hypothesized that the lung endotheliopathy of COVID-19 is caused by circulating host factors and direct endothelial infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Domains
Life Sciences [q-bio]Origin | Publisher files allowed on an open archive |
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