COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective

Jérémie Joffre; Lauren Rodriguez; Zachary A Matthay; Elliot Lloyd; Alexander T Fields; Roland J Bainton; Philip Kurien; Anita Sil; Carolyn S Calfee; Prescott G Woodruff; David J Erle; Carolyn Hendrickson; Matthew F Krummel; Charles R Langelier; Michael A Matthay; Lucy Z Kornblith; Judith Hellman; Sharvari Bhide; Carolyn S Calfee; Sidney A Carrillo; Suzanna Chak; David J Erle; Gabriela K Fragiadakis; Rajani Ghale; Jeremy Giberson; Pat Glenn; Ana Gonzalez; Carolyn Hendrickson; Alejandra Jauregui; Norman Jones; Kirsten Kangelaris; Serena Ke; Matthew F Krummel; Charles R Langelier; Tasha Lea; Deanna Lee; Aleskandra Lelidowicz; Raphael Lota; Michael A Matthay; Jeff Milush; Viet Nguyen; Ahmad Sadeed Rashid; Nicklaus Rodriguez; Austin Sigman; Kevin Tang; Luz Torres Altamirano; Alyssa Ward; Andrew Willmore; Michael Wilson; Prescott G Woodruff; Biniam Ambachew; Sarah Cary; Lauren Chalwell; Christopher Colwell; Chayse Jones; Clayton Josephy; Carolyn Hendrickson; Deanna Lee; Matthieu Legrand; Juan Carlos Montoy; Aaron E Kornblith; Philip Kurien; Brenda Nunez-Garcia; Viet Nguyen; John J Park; Arun Prakash; Brittany Robinson; India Shelley; Katherine D Wick

doi:10.1164/rccm.202107-1774oc

Journal Articles American Journal of Respiratory and Critical Care Medicine Year : 2022

COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective

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Jérémie Joffre

Function : Author

CHU Saint-Antoine [AP-HP]

Centre de Recherche Saint-Antoine

Système immunitaire et neuroinflammation [CRSA]

Lauren Rodriguez

Function : Author

Zachary A Matthay

Function : Author

Elliot Lloyd

Function : Author

Alexander T Fields

Function : Author

Roland J Bainton

Function : Author

Philip Kurien

Function : Author

Anita Sil

Function : Author

Carolyn S Calfee

Function : Author

Prescott G Woodruff

Function : Author

David J Erle

Function : Author
PersonId : 812903
ORCID : 0000-0002-2171-0648

Carolyn Hendrickson

Function : Author

Matthew F Krummel

Function : Author

Charles R Langelier

Function : Author

Michael A Matthay

Function : Author

Lucy Z Kornblith

Function : Author
PersonId : 1235682
ORCID : 0000-0002-1861-9691

Judith Hellman

Function : Author
PersonId : 1235681
ORCID : 0000-0003-2278-6625

Sharvari Bhide

Function : Author

Carolyn S Calfee

Function : Author

Sidney A Carrillo

Function : Author

Suzanna Chak

Function : Author

David J Erle

Function : Author

Gabriela K Fragiadakis

Function : Author

Rajani Ghale

Function : Author

Jeremy Giberson

Function : Author

Pat Glenn

Function : Author

Ana Gonzalez

Function : Author

Carolyn Hendrickson

Function : Author

Alejandra Jauregui

Function : Author

Norman Jones

Function : Author

Kirsten Kangelaris

Function : Author

Serena Ke

Function : Author

Matthew F Krummel

Function : Author

Charles R Langelier

Function : Author

Tasha Lea

Function : Author

Deanna Lee

Function : Author

Aleskandra Lelidowicz

Function : Author

Raphael Lota

Function : Author

Michael A Matthay

Function : Author

Jeff Milush

Function : Author

Viet Nguyen

Function : Author

Ahmad Sadeed Rashid

Function : Author

Nicklaus Rodriguez

Function : Author

Austin Sigman

Function : Author

Kevin Tang

Function : Author

Luz Torres Altamirano

Function : Author

Alyssa Ward

Function : Author

Andrew Willmore

Function : Author

Michael Wilson

Function : Author

Prescott G Woodruff

Function : Author

Biniam Ambachew

Function : Author

Sarah Cary

Function : Author

Lauren Chalwell

Function : Author

Christopher Colwell

Function : Author

Chayse Jones

Function : Author

Clayton Josephy

Function : Author

Carolyn Hendrickson

Function : Author

Deanna Lee

Function : Author

Matthieu Legrand

Function : Author

Juan Carlos Montoy

Function : Author

Aaron E Kornblith

Function : Author

Philip Kurien

Function : Author

Brenda Nunez-Garcia

Function : Author

Viet Nguyen

Function : Author

John J Park

Function : Author

Arun Prakash

Function : Author

Brittany Robinson

Function : Author

India Shelley

Function : Author

Katherine D Wick

Function : Author

Abstract

Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)associated acute respiratory distress syndrome. However, the effects of COVID-19 on the lung endothelium are not well defined. We hypothesized that the lung endotheliopathy of COVID-19 is caused by circulating host factors and direct endothelial infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Life Sciences [q-bio]

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jeremie joffre : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-04022303

Submitted on : Thursday, March 9, 2023-8:55:21 PM

Last modification on : Monday, March 4, 2024-6:24:21 PM

Long-term archiving on: Saturday, June 10, 2023-8:22:05 PM

Dates and versions

hal-04022303 , version 1 (09-03-2023)

Identifiers

HAL Id : hal-04022303 , version 1
DOI : 10.1164/rccm.202107-1774oc

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Jérémie Joffre, Lauren Rodriguez, Zachary A Matthay, Elliot Lloyd, Alexander T Fields, et al.. COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective. American Journal of Respiratory and Critical Care Medicine, 2022, 206, pp.961 - 972. ⟨10.1164/rccm.202107-1774oc⟩. ⟨hal-04022303⟩

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COVID-19–associated Lung Microvascular Endotheliopathy: A “From the Bench” Perspective

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