In this work, a jet of cold plasma is generated in a device supplied in helium and powered with a high-voltage nanopulse power supply, hence generating guided streamers. We focus on the interaction between these guided streamers and two targets placed in a series: a metal mesh target (MM) at floating potential followed by a metal plate target (MP) grounded by a 1500 Ω resistor. We demonstrate that such an experimental setup allows to shift from a physics of streamer repeatability to a physics of streamer self-organization, i.e., from the repetition of guided streamers that exhibit fixed spatiotemporal constants to the emergence of self-organized guided streamers, each of which is generated on the rising edge of a high-voltage pulse. Up to five positive guided streamers can be self-organized one after the other, all distinct in space and time. While self-organization occurs in the capillary and up to the MM target, we also demonstrate the existence of transient emissive phenomena in the inter-target region, especially a filamentary discharge whose generation is directly correlated with complexity order Ω. The mechanisms of the self-organized guided streamers are deciphered by correlating their optical and electrical properties measured by fast ICCD camera and current-voltage probes, respectively. For the sake of clarity, special attention is paid to the case where three selforganized guided streamers (α, β and γ) propagate at vα = 75.7 km•s-1 , vβ = 66.5 km•s-1 and vγ = 58.2 km•s-1), before being accelerated in the vicinity of the MM target.