Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI) - Sorbonne Université Access content directly
Journal Articles Parkinsonism & Related Disorders Year : 2019

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Neha Prakash (1) , Chelsea Caspell-Garcia (2) , Christopher Coffey (2) , Andrew Siderowf (3) , Caroline M Tanner (4) , Karl Kieburtz (5) , Brit Mollenhauer (6) , Douglas Galasko (7) , Kalpana Merchant (8) , Tatiana Foroud , Lana M Chahine (9) , Daniel Weintraub (3) , Cindy Casaceli (5) , Ray Dorsey (5) , Renee Wilson (5) , Margaret Herzog (10) , Nichole Daegele , Vanessa Arnedo (10) , Mark Frasier (10) , Todd Sherer (10) , Ken Marek , Samuel Frank (11) , Danna Jennings (12) , Tanya Simuni (1) , John Seibyl , Duygu Tosun-Turgut , Leslie Shaw , John Trojanowski , Andrew Singleton , Arthur Toga , Werner Poewe , Kathleen Poston , Sohini Chowdhury , Catherine Kopil , Kenneth Marek , Cynthia Casaceli , Sugi Mahes , John Seibyl , Christina Salerno , Arthur Toga , Karen Crawford , Paola Casalin , Giulia Malferrari , Mali Gani Weisz , Avi Orr-Urtreger , John Trojanowski , Leslie Shaw , Andrew Singleton , Thomas Montine , David Russell , Nabila Dahodwala , Werner Poewe , Nir Giladi , Stewart Factor , Penelope Hogarth , David Standaert , Robert Hauser , Joseph Jankovic , Marie Saint-Hilaire , Irene Richard , David Shprecher , Hubert Fernandez , Katrina Brockmann , Liana Rosenthal , Paolo Barone , Alberto Espay , Dominic Rowe , Karen Marder , Anthony Santiago , Susan Bressman , Shu-Ching Hu , Stuart Isaacson , Jean-Christophe Corvol (13, 14) , Javiar Ruiz Martinez , Eduardo Tolosa , Yen Tai , Marios Politis , Debra Smejdir , Linda Rees , Karen Williams , Farah Kausar , Karen Williams , Whitney Richardson , Diana Willeke , Shawnees Peacock , Beatrice Heim , Anat Mirelman , Barbara Sommerfeld , Alison Freed , Katrina Wakeman , Courtney Blair , Stephanie Guthrie , Leigh Harrell , Christine Hunter , Cathi-Ann Thomas , Raymond James , Grace Zimmerman , Victoria Brown , Jennifer Mule , Ella Hilt , Kori Ribb , Susan Ainscough , Misty Wethington , Madelaine Ranola , Helen Mejia Santana , Juliana Moreno , Deborah Raymond , Krista Speketer , Lisbeth Carvajal , Stephanie Carvalho (13) , Ioana Croitoru , Alicia Garrido , Laura Marie Payne , Veena Viswanth , Lawrence Severt , Maurizio Facheris , Holly Soares , Mark A Mintun , Jesse Cedarbaum , Peggy Taylor , Kevin Biglan , Emily Vandenbroucke , Zulfiqar Haider Sheikh , Baris Bingol , Tanya Fischer , Pablo Sardi , Remi Forrat , Alastair Reith , Jan Egebjerg , Gabrielle Ahlberg Hillert , Barbara Saba (15) , Chris Min , Robert Umek , Joe Mather , Susan de Santi , Anke Post , Frank Boess , Kirsten Taylor , Igor Grachev , Andreja Avbersek , Pierandrea Muglia , Kaplana Merchant , Johannes Tauscher
Neha Prakash
  • Function : Author
  • PersonId : 1343380
Christopher Coffey
  • Function : Author
  • PersonId : 1343381
Andrew Siderowf
  • Function : Author
  • PersonId : 1343382
Brit Mollenhauer
  • Function : Author
  • PersonId : 1343383
Tatiana Foroud
  • Function : Author
  • PersonId : 1343384
Lana M Chahine
  • Function : Author
  • PersonId : 1343385
Daniel Weintraub
  • Function : Author
  • PersonId : 1343386
Cindy Casaceli
  • Function : Author
  • PersonId : 1343387
Ray Dorsey
  • Function : Author
  • PersonId : 1343388
Renee Wilson
  • Function : Author
  • PersonId : 1343389
Nichole Daegele
  • Function : Author
  • PersonId : 1343390
Ken Marek
  • Function : Author
Samuel Frank
  • Function : Author
  • PersonId : 1343392
Tanya Simuni
John Seibyl
  • Function : Author
Duygu Tosun-Turgut
  • Function : Author
Leslie Shaw
  • Function : Author
John Trojanowski
  • Function : Author
Andrew Singleton
  • Function : Author
Arthur Toga
  • Function : Author
Werner Poewe
  • Function : Author
Kathleen Poston
  • Function : Author
Sohini Chowdhury
  • Function : Author
Catherine Kopil
  • Function : Author
Kenneth Marek
  • Function : Author
Cynthia Casaceli
  • Function : Author
Sugi Mahes
  • Function : Author
John Seibyl
  • Function : Author
Christina Salerno
  • Function : Author
Arthur Toga
  • Function : Author
Karen Crawford
  • Function : Author
Paola Casalin
  • Function : Author
Giulia Malferrari
  • Function : Author
Mali Gani Weisz
  • Function : Author
Avi Orr-Urtreger
  • Function : Author
John Trojanowski
  • Function : Author
Leslie Shaw
  • Function : Author
Andrew Singleton
  • Function : Author
Thomas Montine
  • Function : Author
David Russell
  • Function : Author
Nabila Dahodwala
  • Function : Author
Werner Poewe
  • Function : Author
Nir Giladi
  • Function : Author
Stewart Factor
  • Function : Author
Penelope Hogarth
  • Function : Author
David Standaert
  • Function : Author
Robert Hauser
  • Function : Author
Joseph Jankovic
  • Function : Author
Marie Saint-Hilaire
  • Function : Author
Irene Richard
  • Function : Author
David Shprecher
  • Function : Author
Hubert Fernandez
  • Function : Author
Katrina Brockmann
  • Function : Author
Liana Rosenthal
  • Function : Author
Paolo Barone
  • Function : Author
Alberto Espay
  • Function : Author
Dominic Rowe
  • Function : Author
Karen Marder
  • Function : Author
Anthony Santiago
  • Function : Author
Susan Bressman
  • Function : Author
Shu-Ching Hu
  • Function : Author
Stuart Isaacson
  • Function : Author
Javiar Ruiz Martinez
  • Function : Author
Eduardo Tolosa
  • Function : Author
Yen Tai
  • Function : Author
Marios Politis
  • Function : Author
Debra Smejdir
  • Function : Author
Linda Rees
  • Function : Author
Karen Williams
  • Function : Author
Farah Kausar
  • Function : Author
Karen Williams
  • Function : Author
Whitney Richardson
  • Function : Author
Diana Willeke
  • Function : Author
Shawnees Peacock
  • Function : Author
Beatrice Heim
  • Function : Author
Anat Mirelman
  • Function : Author
Barbara Sommerfeld
  • Function : Author
Alison Freed
  • Function : Author
Katrina Wakeman
  • Function : Author
Courtney Blair
  • Function : Author
Stephanie Guthrie
  • Function : Author
Leigh Harrell
  • Function : Author
Christine Hunter
  • Function : Author
Cathi-Ann Thomas
  • Function : Author
Raymond James
  • Function : Author
Grace Zimmerman
  • Function : Author
Victoria Brown
  • Function : Author
Jennifer Mule
  • Function : Author
Ella Hilt
  • Function : Author
Kori Ribb
  • Function : Author
Susan Ainscough
  • Function : Author
Misty Wethington
  • Function : Author
Madelaine Ranola
  • Function : Author
Helen Mejia Santana
  • Function : Author
Juliana Moreno
  • Function : Author
Deborah Raymond
  • Function : Author
Krista Speketer
  • Function : Author
Lisbeth Carvajal
  • Function : Author
Ioana Croitoru
  • Function : Author
Alicia Garrido
  • Function : Author
Laura Marie Payne
  • Function : Author
Veena Viswanth
  • Function : Author
Lawrence Severt
  • Function : Author
Maurizio Facheris
  • Function : Author
Holly Soares
  • Function : Author
Mark A Mintun
  • Function : Author
Jesse Cedarbaum
  • Function : Author
Peggy Taylor
  • Function : Author
Kevin Biglan
  • Function : Author
Emily Vandenbroucke
  • Function : Author
Zulfiqar Haider Sheikh
  • Function : Author
Baris Bingol
  • Function : Author
Tanya Fischer
  • Function : Author
Pablo Sardi
  • Function : Author
Remi Forrat
  • Function : Author
Alastair Reith
  • Function : Author
Jan Egebjerg
  • Function : Author
Gabrielle Ahlberg Hillert
  • Function : Author
Chris Min
  • Function : Author
Robert Umek
  • Function : Author
Joe Mather
  • Function : Author
Susan de Santi
  • Function : Author
Anke Post
  • Function : Author
Frank Boess
  • Function : Author
Kirsten Taylor
  • Function : Author
Igor Grachev
  • Function : Author
Andreja Avbersek
  • Function : Author
Pierandrea Muglia
  • Function : Author
Kaplana Merchant
  • Function : Author
Johannes Tauscher
  • Function : Author

Abstract

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC). Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants. Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. All PPMI participants undergo LP at baseline, 6, 12 months and yearly thereafter. CSF collection is performed by a trained investigator using predominantly atraumatic needles. Adverse events (AEs) are monitored by phone one week after LP completion. We analyzed safety data from baseline LPs. Results: PPMI enrolled 683 participants (423 PD/196 HC/64 SWEDDs) from 23 study sites. CSF was collected at baseline in 97.5% of participants, of whom 5.4% underwent collection under fluoroscopy. 23% participants reported any related AEs, 68% of all AE were mild while 5.6% were severe. The most common AEs were headaches (13%) and low back pain (6.5%) and both occurred more commonly in HC and SWEDDs compared to PD participants. Factors associated with higher incidence of AEs across the cohorts included female gender, younger age and use of traumatic needles with larger diameter. AEs largely did not impact compliance with the future LPs. Conclusions: LPs are safe and feasible in PD research participants. Specific LP techniques (needle type and gauge) may reduce the overall incidence of AEs.

Dates and versions

hal-04423774 , version 1 (29-01-2024)

Identifiers

Cite

Neha Prakash, Chelsea Caspell-Garcia, Christopher Coffey, Andrew Siderowf, Caroline M Tanner, et al.. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI). Parkinsonism & Related Disorders, 2019, 62, pp.201-209. ⟨10.1016/j.parkreldis.2018.12.025⟩. ⟨hal-04423774⟩
3 View
3 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More