Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

Quentin M Anstee; Rebecca Darlay; Simon Cockell; Marica Meroni; Olivier Govaere; Dina Tiniakos; Alastair D Burt; Pierre Bedossa; Jeremy Palmer; Yang-Lin Liu; Guruprasad P Aithal; Michael Allison; Hannele Yki-Järvinen; Michele Vacca; Jean-Francois Dufour; Pietro Invernizzi; Daniele Prati; Mattias Ekstedt; Stergios Kechagias; Sven Francque; Salvatore Petta; Elisabetta Bugianesi; Karine Clement; Vlad Ratziu; Jörn M Schattenberg; Luca Valenti; Christopher P Day; Heather J Cordell; Ann K Daly

doi:10.1016/j.jhep.2020.04.003

Journal Articles Journal of Hepatology Year : 2020

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

, , , , , , , , , , , , , , , , , , , , , , (1) , (1) , , , , ,

Quentin M Anstee

Function : Author
PersonId : 1358543

Rebecca Darlay

Function : Author

Simon Cockell

Function : Author

Marica Meroni

Function : Author

Olivier Govaere

Function : Author

Dina Tiniakos

Function : Author

Alastair D Burt

Function : Author

Pierre Bedossa

Function : Author

Jeremy Palmer

Function : Author

Yang-Lin Liu

Function : Author

Guruprasad P Aithal

Function : Author

Michael Allison

Function : Author

Hannele Yki-Järvinen

Function : Author

Michele Vacca

Function : Author

Jean-Francois Dufour

Function : Author

Pietro Invernizzi

Function : Author

Daniele Prati

Function : Author

Mattias Ekstedt

Function : Author

Stergios Kechagias

Function : Author

Sven Francque

Function : Author

Salvatore Petta

Function : Author

Elisabetta Bugianesi

Function : Author

Karine Clement

Function : Author

Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière]

Vlad Ratziu

Function : Author

Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière]

Jörn M Schattenberg

Function : Author

Luca Valenti

Function : Author

Christopher P Day

Function : Author

Heather J Cordell

Function : Author

Ann K Daly

Function : Author
PersonId : 1358544

Abstract

PNPLA3 TM6SF2 GCKR Chromosome-log10(p) 1,483 NAFLD cases and 17,781 population controls Genome-wide association study Histologically confirmed NAFLD Replication cohort of 559 NAFLD cases and 945 controls genotyped for top SNPs Highlights Genome-wide association study involved 1,483 biopsied NAFLD cases and 17,781 controls. Main analysis shows genome-wide significance for PNPLA3, TM6SF2, HSD17B13 and GCKR. Sub-analyses show significance near LEPR for NASH and near PYGO1 for steatosis. Except for GCKR, the genome-wide significant signals were replicated.

Keywords

NAFLD NASH Fibrosis GWAS PNPLA3 TM6SF2 GCKR HSD17B13 SNP

Domains

Human health and pathology

Fichier principal

PIIS0168827820302130.pdf (1.27 Mo)

Origin	Publication funded by an institution
Licence	Attribution - NonCommercial - NoDerivatives

Gestionnaire HAL 2 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-04483993

Submitted on : Thursday, February 29, 2024-2:45:09 PM

Last modification on : Friday, March 1, 2024-3:28:01 AM

Long-term archiving on: Thursday, May 30, 2024-7:14:03 PM

Dates and versions

hal-04483993 , version 1 (29-02-2024)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

HAL Id : hal-04483993 , version 1
DOI : 10.1016/j.jhep.2020.04.003
PUBMED : 32298765

Cite

Quentin M Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, et al.. Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort. Journal of Hepatology, 2020, 73 (3), pp.505-515. ⟨10.1016/j.jhep.2020.04.003⟩. ⟨hal-04483993⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

ICAN SORBONNE-UNIVERSITE SU-MEDECINE IHU_ICAN

28 View

9 Download

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

Abstract

Keywords

Domains

Dates and versions

Licence

Identifiers

Cite

Export

Collections

Altmetric

Share