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Journal Articles Journal of Hepatology Year : 2020

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort

Quentin M Anstee
  • Function : Author
  • PersonId : 1358543
Rebecca Darlay
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Simon Cockell
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Marica Meroni
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Olivier Govaere
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Dina Tiniakos
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Alastair D Burt
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Pierre Bedossa
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Jeremy Palmer
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Yang-Lin Liu
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Guruprasad P Aithal
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Michael Allison
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Hannele Yki-Järvinen
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Michele Vacca
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Jean-Francois Dufour
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Pietro Invernizzi
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Daniele Prati
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Mattias Ekstedt
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Stergios Kechagias
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Sven Francque
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Salvatore Petta
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Elisabetta Bugianesi
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Jörn M Schattenberg
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Luca Valenti
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Christopher P Day
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Heather J Cordell
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Ann K Daly
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  • PersonId : 1358544

Abstract

PNPLA3 TM6SF2 GCKR Chromosome-log10(p) 1,483 NAFLD cases and 17,781 population controls Genome-wide association study Histologically confirmed NAFLD Replication cohort of 559 NAFLD cases and 945 controls genotyped for top SNPs Highlights Genome-wide association study involved 1,483 biopsied NAFLD cases and 17,781 controls. Main analysis shows genome-wide significance for PNPLA3, TM6SF2, HSD17B13 and GCKR. Sub-analyses show significance near LEPR for NASH and near PYGO1 for steatosis. Except for GCKR, the genome-wide significant signals were replicated.
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Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

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hal-04483993 , version 1 (29-02-2024)

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Attribution - NonCommercial - NoDerivatives

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Quentin M Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, et al.. Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort. Journal of Hepatology, 2020, 73 (3), pp.505-515. ⟨10.1016/j.jhep.2020.04.003⟩. ⟨hal-04483993⟩
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