Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort
Résumé
PNPLA3 TM6SF2 GCKR Chromosome-log10(p) 1,483 NAFLD cases and 17,781 population controls Genome-wide association study Histologically confirmed NAFLD Replication cohort of 559 NAFLD cases and 945 controls genotyped for top SNPs Highlights Genome-wide association study involved 1,483 biopsied NAFLD cases and 17,781 controls. Main analysis shows genome-wide significance for PNPLA3, TM6SF2, HSD17B13 and GCKR. Sub-analyses show significance near LEPR for NASH and near PYGO1 for steatosis. Except for GCKR, the genome-wide significant signals were replicated.
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