Characteristics of subjective cognitive decline associated with amyloid positivity - Sorbonne Université Access content directly
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2021

Characteristics of subjective cognitive decline associated with amyloid positivity

Olin Janssen
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Sylvia Villeneuve
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Julius Popp
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Chris Rowe
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Steffen Wolfsgruber
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Michael Heneka
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Henning Boecker
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Oliver Peters
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Jonas Jarholm
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Lorena Rami
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Adrià Tort-Merino
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Alexa Pichet Binette
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Judes Poirier
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Pedro Rosa-Neto
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Jiri Cerman
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Daniel Alcolea
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Juan Fortea
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M Belén Sánchez-Saudinós
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Jarith Ebenau
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Cornelia Pocnet
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Marie Eckerström
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Louisa Thompson
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Victor Villemagne
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Rachel Buckley
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Samantha Burnham
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Marion Delarue
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Yvonne Freund-Levi
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Åsa K Wallin
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Inez Ramakers
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Magda Tsolaki
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Hilkka Soininen
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Harald Hampel
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Luiza Spiru
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Betty Tijms
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Rik Ossenkoppele
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Frans R J Verhey
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Frank Jessen
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Pieter Jelle Visser
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Stephanie J.B. Vos
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M. Belén Sánchez-Saudinós
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Abstract

Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
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Dates and versions

hal-04524946 , version 1 (28-03-2024)

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Attribution - NonCommercial

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Olin Janssen, Willemijn J Jansen, Stephanie Vos, Merce Boada, Lucilla Parnetti, et al.. Characteristics of subjective cognitive decline associated with amyloid positivity. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, 18 (10), pp.1832-1845. ⟨10.1002/alz.12512⟩. ⟨hal-04524946⟩
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